gene 1,597 words KG: NR1D2
Contents

NR1D2 (Nuclear Receptor Subfamily 1 Group D Member 2)

🧬 Gene Info
Gene SymbolNR1D2
AliasesREV-ERBβ
Chromosome3p24.2.
Protein TypeReceptor
Functionis a nuclear receptor protein that functions as a transcriptional repressor and plays a critical role in the molecular circadian clock[@partch2014].
Molecular Weight51 kDa
Amino Acids478 aa
Ensembl IDENSG00000150051
GeneCardsNR1D2
Human Protein AtlasNR1D2
Associated DiseasesParkinson's disease, Alzheimer's disease
KG Connections10 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (11)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38

Related Analyses (4)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

REV-ERB pharmacological activation blocks SD effects
validation · proposed · Score: 0.90
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (9)

Neurodegeneration
disease · KG edge: implicated_in
ABCG1 Gene
gene · KG edge: expressed_in
CKAP4 — Cytoskeleton-Associated Protein 4
gene · KG edge: associated_with
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: expressed_in
Lysosomal Associated Membrane Protein 3 (LAMP3)
gene · KG edge: expressed_in

Knowledge Graph (10 edges)

NR1D2 associated_with CKAP4
NR1D2 expressed_in GAIN
NR1D2 expressed_in LAMP3
NR1D2 expressed_in ABCG1
NR1D2 associated_with RORA
NR1D2 expressed_in TGM2
NR1D2 expressed_in PIK3R1
NR1D2 expressed_in WTAP
NR1D2 expressed_in Als
NR1D2 inhibits microglial_activation

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