gene 1,735 words KG: MBD1
Contents

MBD1 — Methyl-CpG Binding Domain Protein 1

🧬 Gene Info
Gene SymbolMBD1
Full NameMethyl-CpG Binding Domain Protein 1
Chromosome18q21.1
Protein FamilyMBD (Methyl-CpG Binding Domain)
Functionis a critical epigenetic regulator that binds to methylated CpG dinucleotides in DNA and recruits chromatin remodeling complexes to silence gene expression.
Molecular Weight66 kDa
Amino Acids605 aa
Exons17
PathwaysDna Methylation, epigenetic regulation
UniProt IDQ9P273
NCBI Gene ID4153
Ensembl IDENSG00000141644
OMIM156311
GeneCardsMBD1
Human Protein AtlasMBD1
Associated Diseasesneurodegeneration
InteractionsC-FOS, EZH2, FOS, SDHB, VHL
KG Connections10 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (14)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (12)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (7)

Neurodegeneration
disease · KG edge: implicated_in
DNA Methylation
entity · KG edge: activates
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: associated_with
FOS Gene
gene · KG edge: activates
SDHB Gene
gene · KG edge: activates

Knowledge Graph (10 edges)

VHL activates MBD1
MBD1 activates FOS
MBD1 activates SDHB
MBD1 associated_with TREM2
EZH2 interacts_with MBD1
MBD1 activates C-FOS
MBD1 activates Als
MBD1 activates Dna Methylation
MBD1 binds TREK-1
MBD1 participates_in epigenetic regulation

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)