gene 3,338 words KG: LRP1B
Contents

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

🧬 Gene Info
Gene SymbolLRP1B
Full NameLow Density Lipoprotein Receptor-Related Protein 1B
AliasesPage for LRP1B Protein
Chromosome2q22.1
Protein TypeProtein
Functionis a very large LDL receptor-family transmembrane protein that functions as an endocytic and signaling regulator in epithelial and neuronal systems.
Molecular Weight500 kDa
Amino Acids595 aa
Exons92
PathwaysMAPK, PI3K, Wnt signaling
UniProt IDSearch UniProt
GeneCardsLRP1B
Human Protein AtlasLRP1B
Associated DiseasesAging, Als, Atherosclerosis, cancer
InteractionsAPOE, APOPTOSIS, CANCER, LDL, PAH, PD-1
KG Connections98 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
← Prevpg 2/2

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (3)

Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Tau Propagation Causality Test — Does Tau Spread Drive Neuro
clinical · proposed · Score: 0.40

See Also (15)

Endosomal Sorting Defects in Neurodegeneration
mechanism · Pages share 6 hypotheses
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 6 hypotheses
Cerebral Amyloid Angiopathy Pathway in Neurodegeneratio
mechanism · Pages share 6 hypotheses
Endosomal-Lysosomal Pathway in Neurodegeneration
mechanism · Pages share 6 hypotheses
RNA-Targeted Therapies in Neurodegeneration
mechanism · Pages share 6 hypotheses

Knowledge Graph (12 edges)

LRP8 associated_with LRP1B
LRP5 associated_with LRP1B
LRP1 associated_with LRP1B
LRP2 associated_with LRP1B
LRP1B associated_with LRP4
LRP1B associated_with PAH
LRP1B associated_with LDLR
LRP1B associated_with LRP5
LRP1B associated_with LRP1
LRP1B associated_with LRP8

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