gene 3,338 words KG: LRP1B
Contents

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

🧬 Gene Info
Gene SymbolLRP1B
Full NameLow Density Lipoprotein Receptor-Related Protein 1B
AliasesPage for LRP1B Protein
Chromosome2q22.1
Protein TypeProtein
Functionis a very large LDL receptor-family transmembrane protein that functions as an endocytic and signaling regulator in epithelial and neuronal systems.
Molecular Weight500 kDa
Amino Acids595 aa
Exons92
PathwaysMAPK, PI3K, Wnt signaling
UniProt IDSearch UniProt
GeneCardsLRP1B
Human Protein AtlasLRP1B
Associated DiseasesAging, Als, Atherosclerosis, cancer
InteractionsAPOE, APOPTOSIS, CANCER, LDL, PAH, PD-1
KG Connections98 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
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Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (3)

Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Tau Propagation Causality Test — Does Tau Spread Drive Neuro
clinical · proposed · Score: 0.40

See Also (15)

Endosomal Sorting Defects in Neurodegeneration
mechanism · Pages share 6 hypotheses
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 6 hypotheses
Cerebral Amyloid Angiopathy Pathway in Neurodegeneratio
mechanism · Pages share 6 hypotheses
Endosomal-Lysosomal Pathway in Neurodegeneration
mechanism · Pages share 6 hypotheses
RNA-Targeted Therapies in Neurodegeneration
mechanism · Pages share 6 hypotheses

Knowledge Graph (12 edges)

LRP8 associated_with LRP1B
LRP5 associated_with LRP1B
LRP1 associated_with LRP1B
LRP2 associated_with LRP1B
LRP1B associated_with LRP4
LRP1B associated_with PAH
LRP1B associated_with LDLR
LRP1B associated_with LRP5
LRP1B associated_with LRP1
LRP1B associated_with LRP8

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