| Gene Symbol | **ANK2** (Ankyrin-B) |
| Full Name | Ankyrin-2 |
| Chromosome | 4q22-q25 |
| Protein Family | Ankyrin repeat proteins |
| Protein Type | Adaptor Protein |
| Primary Expression | Heart (cardiac myocytes), brain (cortex, hippocampus, cerebellum), skeletal muscle, retina |
| Subcellular Localization | the sarcoplasmic reticulum and T-tubules |
| Amino Acids | 300 aa |
| UniProt ID | Q01484 |
| NCBI Gene ID | 287 |
| Ensembl ID | ENSG00000145362 |
| OMIM | 106410 |
| N-terminal Domain | Contains 24 ankyrin repeats that mediate protein-protein interactions with membrane proteins |
| Spectrin-Binding Domain | The central region binds to β-spectrin, linking membrane proteins to the cytoskeleton |
| C-terminal Regulatory Domain | Contains death domain homology regions involved in signaling |
| Associated Diseases | Long QT Syndrome 4, Cardiac Hypertrophy, Autism Spectrum Disorder, Intellectual Disability, Neurodevelopmental Delay |
| Interactions | COMPLEMENT, IGF2BP1, PTEN |
| SciDEX Hypotheses | Neuronal-specific domain stabilization |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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