gene 916 words KG: GBA3
Contents

GBA3 — Glucosidase Beta 3

🧬 Gene Info
Gene SymbolGBA3
Full NameGlucosidase Beta 3
Chromosome4p15.2
Protein TypeHydrolase
Functionencodes a member of the glycoside hydrolase family, specifically a lysosomal glucocerebrosidase enzyme.
Amino Acids556 aa
UniProt IDQ9Y5K2
NCBI Gene ID57733
GeneCardsGBA3
Human Protein AtlasGBA3
Associated DiseasesHypertension, Ms
InteractionsCOMT, CYP2C18, CYP3A5, SLC22A2, UGT3A1
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (5)

Lysosomal Positioning Dynamics Modulation
Score: 0.69
Sphingolipid Metabolism Reprogramming
Score: 0.62
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.98
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69

Related Analyses (3)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (5)

Neurodegeneration
disease · KG edge: implicated_in
Insulin Receptor Substrate 1 (IRS-1)
entity · KG edge: associated_with
COMT Gene
gene · KG edge: associated_with
slc22a2
gene · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with

Knowledge Graph (12 edges)

GBA3 associated_with COMT
GBA3 associated_with SLC22A2
COMT associated_with GBA3
SLC22A2 associated_with GBA3
GBA3 regulates Metabolite Levels
GBA3 interacts_with SLC22A2
GBA3 interacts_with COMT
COMT interacts_with GBA3
GBA3 associated_with Hypertension
GBA3 associated_with Ms

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