gene 530 words KG: FGF2
Contents

FGF2 — Fibroblast Growth Factor 2

🧬 Gene Info
Gene SymbolFGF2
Full NameFibroblast Growth Factor 2
Chromosome4q28
FunctionFGF2 (basic FGF) encodes a member of the fibroblast growth factor family that binds to FGFR1-4 with varying affinities.
PathwaysAkt, Mapk, Pi3K, Pi3K/Akt
UniProt ID[P09038](https://www.uniprot.org/uniprot/P09038)
Ensembl IDENSG00000108639
OMIM134760
GeneCardsFGF2
Human Protein AtlasFGF2
Associated DiseasesAging, ALS, ANGIOGENESIS, Cancer, Carcinoma, CELL PROLIFERATION
InteractionsAND, ANGPT1, App, APP, AUTOPHAGY,
KG Connections474 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (21)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Glial Glycocalyx Remodeling Therapy
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Glycosaminoglycan Template Disruption Approach
Score: 0.60
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Related Analyses (10)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (5)

Irisin effects on angiogenesis in human endothelial cells
exploratory · proposed · Score: 0.90
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (15)

Alzheimer Indonesia
institution · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

Knowledge Graph (12 edges)

BMP2 activates FGF2
VEGF activates FGF2
FGF2 activates ANGPT1
FGF2 activates PDGFRB
FGF2 activates VEGFB
FGF1 interacts_with FGF2
ERK1 activates FGF2
CSF2 regulates FGF2
NAMPT regulates FGF2
FGF2 regulates CXCL10

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