| Gene Symbol | FCGRT |
| Full Name | Fc fragment of IgG receptor and transporter |
| Chromosome | 19q13.33 |
| Protein Family | transporter |
| Target Class | Transporter |
| Function | functions as a neonatal Fc receptor (FcRn), responsible for the bidirectional transport of immunoglobulin G (IgG) across epithelial and endothelial barriers |
| Mechanism of Action | Monoclonal antibody blocking FcRn-mediated IgG recycling |
| Primary Expression | midbrain, Cortex, Hippocampus, Cerebellum |
| Druggability | Medium (0.51) |
| Clinical Stage | Approved |
| Pathways | Lysosomal Degradation, Blood-Brain Barrier, neuroinflammation, Neuroinflammatory, Neonatal Fc receptor / antibody transcytosis |
| GeneCards | FCGRT |
| Human Protein Atlas | FCGRT |
| β2-microglobulin | Essential cofactor for FCGRT function |
| Blood-brain barrier (BBB) | Primary site of FCGRT-mediated immune surveillance |
| Associated Diseases | Alzheimer, Ivig Effectiveness, Myasthenia Gravis, neurodegeneration, Parkinson, schizophrenia |
| Known Drugs/Compounds | Humanized Monoclonal Antibodies, Tfrmab, TfRMAb-EPO, TfRMAb fusion protein, Tfrmab-Tnfr, TfRMAb-TNFR |
| Interactions | ACE2, AND, APOC1, C1QA, C1QC, CD14 |
| SciDEX Target | View Target Profile (6 clinical trials) |
| SciDEX Hypotheses | Dual-Domain Antibodies with Engineered Fc-FcRn Aff |
| KG Connections | 214 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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