| Gene Symbol | DLGAP2 |
| Chromosome | 8p23.3 |
| Protein Type | Scaffold Protein |
| Function | DLGAP2 is a core component of the postsynaptic density complex, where it mediates interactions between glutamate receptors, particularly AMPA receptors, and the underlying cytoskeleton. |
| Primary Expression | the brain, particularly in: - Cerebral cortex - Hippocampus - Striatum (for DLGAP3) - [Cerebell |
| UniProt ID | O75179 |
| NCBI Gene ID | 9228 |
| Ensembl ID | ENSG00000198010 |
| GeneCards | DLGAP2 |
| Human Protein Atlas | DLGAP2 |
| Autism Spectrum Disorder | Rare variants in DLGAP2 have been identified in patients with ASD. |
| Intellectual Disability | Loss-of-function mutations contribute to intellectual disability phenotypes. |
| Obsessive-Compulsive Disorder | DLGAP2 (particularly SAPAP3/DLGAP3) has been linked to OCD-like behaviors in mouse models. |
| Associated Diseases | Ms |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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