gene 1,741 words KG: DDX1
Contents

DDX1 Gene

🧬 Gene Info
Gene SymbolDDX1
Functionencodes an ATP-dependent RNA helicase that belongs to the highly conserved DEAD-box protein family.
Primary ExpressionHippocampus
Amino Acids724 aa
PathwaysAmyloid
Ensembl IDENSG00000136531
GeneCardsDDX1
Human Protein AtlasDDX1
Helicase activityUnwinding of RNA duplexes
ATPase activityATP hydrolysis provides energy for conformational changes
RNA bindingDirect binding to various RNA substrates
Annealing activityCan also promote RNA-RNA annealing
N-terminal extensionContains nuclear localization signals
Associated DiseasesAlzheimer, Alzheimer's disease, Dementia, disease
InteractionsPRMT1, USP1
KG Connections63 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47
← Prevpg 2/2

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Microglia
cell · KG edge: associated_with
ABCA7 (Redirect)
redirect · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
GBA (Redirect)
redirect · KG edge: associated_with
GRN Carrier Resilience: Why Some Mutation Carriers Rema
general · KG edge: associated_with

Knowledge Graph (12 edges)

SORL1 associated_with DDX1
ABCA7 associated_with DDX1
ADAM10 associated_with DDX1
DDX1 associated_with PSEN1
DDX1 associated_with GBA
DDX1 associated_with GRN
GRN associated_with DDX1
TGM2 associated_with DDX1
PSEN1 associated_with DDX1
DDX1 associated_with TGM2

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