Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about USP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | USP1 |
| Key Genes/Proteins | DDX1, DNA, FOXO1, PRMT1 |
| Related Diseases | Parp Inhibitor Sensitivity |
| Related Pathways | PARP Trapping |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
USP1["USP1"]
USP1 -->|"interacts"| PARP1["PARP1"]
USP1 -->|"regulates"| PARP1_Chromatin_Trapping["PARP1 Chromatin Trapping"]
USP1 -->|"regulates"| PARP_Trapping["PARP Trapping"]
USP1 -->|"modulates"| PARylation_Activity["PARylation Activity"]
USP1 -->|"regulates"| Parp1_Chromatin_Trapping["Parp1 Chromatin Trapping"]
PARP1 -->|"substrate_of"| USP1| Target | Relation | Type | Str |
|---|---|---|---|
| PARP1 | interacts_with | entity | 0.95 |
| PARP1 | regulates | entity | 0.95 |
| K63-linked polyubiquitination | inhibits | process | 0.91 |
| PARylation Activity | modulates | process | 0.90 |
| TAZ | associated_with | gene | 0.90 |
| PARP1 | degrades | protein | 0.90 |
| PARP Trapping | regulates | mechanism | 0.90 |
| PARP1 | associated_with | gene | 0.90 |
| Parp1 Chromatin Trapping | regulates | process | 0.90 |
| Parylation | regulates | process | 0.90 |
| OVARIAN CANCER | therapeutic_target | entity | 0.85 |
| Parp Inhibitor Sensitivity | regulates | phenotype | 0.85 |
| replicative stress | regulates | process | 0.80 |
| FOXO1 | interacts_with | gene | 0.80 |
| PARP1 PARylation | regulates | process | 0.80 |
| cell death | promotes | process | 0.75 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| USP14 Inhibition to Accelerate Proteasomal Degradation of Sy | 0.481 | proteomics | Quantitative proteomics of the aging syn |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning USP1 in their description or question text
No additional research found