gene 2,217 words KG: CXCR5
Contents

CXCR5 Gene

🧬 Gene Info
Gene SymbolCXCR5
Full NameC-X-C Chemokine Receptor Type 5
Chromosome11q23.3
Protein FamilyChemokine receptors (GPCR family)
Protein TypeReceptor
Functionis a G protein-coupled receptor that binds specifically to the chemokine CXCL13 (also known as BLC, BCA-1, and B lymphocyte chemoattractant).
Amino Acids372 aa
Exons5
PathwaysNF-κB
UniProt IDP41970
NCBI Gene ID935
Ensembl IDENSG00000169679
OMIM601745
GeneCardsCXCR5
Human Protein AtlasCXCR5
Associated DiseasesCancer, Colorectal Cancer
InteractionsCCL25, CD4, CX3CL1, CX3CR1, TGF
KG Connections16 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (4)

APOE-Dependent Autophagy Restoration
Score: 0.88
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (10)

Neurodegeneration
disease · KG edge: implicated_in
DNA Methylation
entity · KG edge: associated_with
Tumor Necrosis Factor (TNF)
entity · KG edge: therapeutic_target
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: regulates

Knowledge Graph (12 edges)

CXCR5 activates CX3CL1
CXCR5 activates CCL25
CXCR5 activates CX3CR1
CD4 activates CXCR5
CXCR5 therapeutic_target Tumor
CXCR5 therapeutic_target Autoimmune
CXCR5 associated_with DNA
CXCR5 associated_with CANCER
CXCR5 regulates GENES
CXCR5 associated_with Colorectal Cancer

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