gene 939 words KG: CLEC7A
Contents

CLEC7A Gene

🧬 Gene Info
Gene SymbolCLEC7A
Protein TypeReceptor
FunctionCLEC7A encodes a type II transmembrane protein with an extracellular C-type lectin domain and an intracellular immunoreceptor tyrosine-based activation motif (ITAM)-like hemITAM.
PathwaysAmyloid, unfolded protein response, lipid metabolism
Ensembl IDENSG00000172243
GeneCardsCLEC7A
Human Protein AtlasCLEC7A
NFATgene transcription for immune activation
CARD9/BCL10/MALT1inflammasome-independent cytokine production
Associated Diseasesischemic stroke, Parkinson's disease
InteractionsAKT3, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOE, AXL
KG Connections51 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (21)

Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
← Prevpg 2/2

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (1)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (9)

Microglia
cell · KG edge: activates
Neurodegeneration
disease · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Microglia in Neurodegeneration
entity · KG edge: activates
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: activates

Knowledge Graph (12 edges)

CLEC7A regulates Gal3
CLEC7A regulates TREM2
CLEC7A activates Syk
CLEC7A regulates NOX2
CLEC7A associated_with ischemic stroke
APOE activates CLEC7A
CLEC7A activates TREM2
AXL activates CLEC7A
CD9 activates CLEC7A
CLEC7A activates CTSB

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