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gene 939 words KG: CLEC7A
Contents

CLEC7A Gene

🧬 Gene Info
Gene SymbolCLEC7A
Protein TypeReceptor
FunctionCLEC7A encodes a type II transmembrane protein with an extracellular C-type lectin domain and an intracellular immunoreceptor tyrosine-based activation motif (ITAM)-like hemITAM.
PathwaysAmyloid, unfolded protein response, lipid metabolism
Ensembl IDENSG00000172243
GeneCardsCLEC7A
Human Protein AtlasCLEC7A
NFATgene transcription for immune activation
CARD9/BCL10/MALT1inflammasome-independent cytokine production
Associated Diseasesischemic stroke, Parkinson's disease
InteractionsAKT3, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOE, AXL
KG Connections53 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (21)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78CYP46A1 Overexpression Gene Therapy
Score: 0.77APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70Microglial Purinergic Reprogramming
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66TREM2-Dependent Microglial Senescence Transition
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
pg 1/2Next →

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedSynaptic pruning by microglia in early AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (1)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (9)

Microglia
cell · KG edge: activatesNeurodegeneration
disease · KG edge: activatesAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesMicroglia in Neurodegeneration
entity · KG edge: activatesTREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: activates

Knowledge Graph (12 edges)

CLEC7A regulates Gal3
CLEC7A regulates TREM2
CLEC7A activates Syk
CLEC7A regulates NOX2
CLEC7A associated_with ischemic stroke
APOE activates CLEC7A
CLEC7A activates TREM2
AXL activates CLEC7A
CD9 activates CLEC7A
CLEC7A activates CTSB

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