gene 1,663 words KG: CALCINEURIN
Contents

PPP3CA — Protein Phosphatase 3 Catalytic Subunit Alpha

🧬 Gene Info
Gene SymbolPPP3CA
Full NameProtein Phosphatase 3 Catalytic Subunit Alpha (Calcineurin)
AliasesCalcineurin
Chromosome4p16.3
Protein TypePhosphatase
Functionis a unique calcium/calmodulin-dependent phosphatase that plays critical roles in neuronal signal transduction, synaptic plasticity, gene transcription, and immune cell activation[@klee1979].
Primary Expressiona tissue-specific manner:
Molecular Weight59 kDa
Amino Acids521 aa
Exons14
GeneCardsPPP3CA
Human Protein AtlasPPP3CA
Associated DiseasesAxon Repulsion, neurodegeneration
InteractionsNLRP3
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (31)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
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Related Analyses (15)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (4)

Trehalose-induced lysosomal changes and TFEB activation
exploratory · proposed · Score: 0.90
Trehalose-induced lysosomal membrane permeabilization and TF
exploratory · proposed · Score: 0.90
PPP3/calcineurin-dependent TFEB dephosphorylation mechanism
exploratory · proposed · Score: 0.80
Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (10)

Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with
Astrocytes
entity · KG edge: activates
AIFM1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

STIP1 activates CALCINEURIN
LGALS3 activates CALCINEURIN
HSPA8 activates CALCINEURIN
MCOLN1 activates CALCINEURIN
SQSTM1 activates CALCINEURIN
SOD1 activates CALCINEURIN
BCL2 activates CALCINEURIN
CTSB activates CALCINEURIN
TPP1 activates CALCINEURIN
GLA activates CALCINEURIN

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