gene 777 words KG: ent-gene-171ad550
Contents

ARNT - Aryl Hydrocarbon Receptor Nuclear Translocator

🧬 Gene Info
Gene SymbolARNT
Full NameAryl Hydrocarbon Receptor Nuclear Translocator
Protein TypeGene
FunctionARNT is an essential transcriptional cofactor
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Circadian Rhythm
GeneCardsARNT
Human Protein AtlasARNT
Hypoxia responseHeterodimerizes with HIF1α and HIF2α to activate hypoxia-responsive genes
Circadian clockPartners with CLOCK and BMAL1 in the circadian transcriptional complex
Xenobiotic responseWorks with aryl hydrocarbon receptor (AHR)
DevelopmentCritical for embryonic development, especially vascular formation
Associated DiseasesAging, ALS, Alzheimer, Atherosclerosis, Cancer, Cardiac
InteractionsAHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ANXIETY
KG Connections363 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (22)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Circadian Clock-Autophagy Synchronization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
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Related Analyses (12)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

See Also (6)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: regulates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (2 edges)

ent-gene-171ad550 data_in benchmark_ot_ad_answer_key:ARNT
benchmark_ot_ad_answer_key:ARNT data_in ent-gene-171ad550

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