gene 1,699 words KG: FTH1
Contents

FTH1 Gene — Ferritin Heavy Chain 1

🧬 Gene Info
Gene SymbolFTH1
Full NameFerritin Heavy Chain 1
Chromosome19q13.33
Protein FamilyFerritin heavy chain subunit
Functionis a hallmark of multiple neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS)[@ward2014].
Molecular Weight21 kDa
Exons4
PathwaysApoptosis, Blood-Brain Barrier, Ferroptosis, Metastasis, Mitophagy
UniProt IDP02794
NCBI Gene ID2495
Ensembl IDENSG00000196950
OMIM134790
GeneCardsFTH1
Human Protein AtlasFTH1
Ferroxidase centerLocated in FTH1, catalyzes Fe2+ -> Fe3+ oxidation
Associated DiseasesALS, Carcinoma, Hepatocellular Carcinoma, Parkinson's disease, stroke, Tumor
Known Drugs/Compoundsdimethyl malonate, paricalcitol
InteractionsACSL4, ACTB, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA
KG Connections322 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (1)

Iron-driven lipid peroxidation and GPX4 failure create a fer
Score: 0.75

Knowledge Graph (12 edges)

paricalcitol activates FTH1
TFR1 inhibits FTH1
FTH1 inhibits GPX4
SQSTM1 associated_with FTH1
TNF associated_with FTH1
ELAVL1 associated_with FTH1
GPX4 associated_with FTH1
SLC7A11 associated_with FTH1
FTH1 associated_with P62
FTH1 associated_with MAP1LC3A

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