Contents

MAPT — Microtubule Associated Protein Tau Gene Entity

🧬 Gene Info

Gene Symbol	MAPT
Full Name	Microtubule Associated Protein Tau Gene Entity
Aliases	H1/H2
Chromosome	17q21.31
Protein Type	Structural Protein
Target Class	Structural Protein
Function	Tau aggregation inhibitors, anti-tau antibodies, tau phosphorylation modulators
Mechanism of Action	Tau aggregation inhibitors, anti-tau antibodies, tau phosphorylation modulators
Druggability	Medium (0.45)
Clinical Stage	Phase III
Molecular Weight	65 kDa
Amino Acids	441 aa
Exons	16
Pathways	Amyloid, Apoptosis, Autophagy, Camp Signaling, Cholesterol
UniProt ID	A0A7I2PJZ2
GeneCards	MAPT
Human Protein Atlas	MAPT
Associated Diseases	AD, Ad Pathology, Aging, Als, Alzheimer
Known Drugs/Compounds	13G4, berberine, Flavonoids
Interactions	A2M, ACE, ACHE, Actin, AD, AGING
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Glymphatic-Mediated Tau Clearance Dysfunction Excitatory Neuron Synaptic Dysfunction and Mitocho Dual-Circuit Tau Vulnerability Cascade (+18 more)
KG Connections	1976 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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