entity 584 words KG: autophagy
Contents

Autophagy

🔬 Protein Info
Gene Symbolautophagy
AliasesAutophagy-lysosomal pathway, Cellular self-eating
FunctionProtein degradation; Organelle turnover; Quality control
PathwaysmTOR pathway, AMPK signaling, Beclin-1 complex
Associated Diseasesadipogenesis, ALS, Alzheimer's disease, Alzheimer's disease and related dementias, AMD, amyotrophic lateral sclerosis
Known Drugs/Compoundsarsenic, ATTECs, calycosin, Calycosin, CDK4/6 inhibitors, cocaine
KG Connections689 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (30)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.92
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.85
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81

Related Analyses (30)

How do non-cell autonomous effects of autophagy dysfunction
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (30)

P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90
Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90
Trehalose-induced lysosomal changes and TFEB activation
exploratory · proposed · Score: 0.90
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
Trehalose-induced lysosomal membrane permeabilization and TF
exploratory · proposed · Score: 0.90

See Also (4)

ABCA7 (Redirect)
redirect · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
ABCG1 Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

autophagy regulates ferroptosis
ULK1 activates autophagy
autophagy activates bacterial_clearance
autophagy activates NRF2
autophagy treats neurodegeneration
autophagy regulates intestinal_epithelium
autophagy regulates tight_junctions
autophagy activates barrier_function
autophagy regulates intestinal_stem_cells
autophagy regulates secretory_cells

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