| Prevalence | ~10-15% of familial AD cases |
| Typical Onset | ~50-60 years |
| Inheritance | Autosomal dominant |
| Gene | APP (Amyloid Precursor Protein) |
| Chromosome | 21q21.3 |
| Mutation Count | >40 pathogenic mutations identified |
| Neuronal development | Promotes neurite outgrowth and synaptic formation |
| Synaptic plasticity | Modmission |
| ulates excitatory | BMetal homeostasis neurotransinds copper, zinc, and iron |
| Cellular stress response | Activates protective pathways |
| Location | Aβ24 (D23N, "Iowa") |
| Effect | Enhanced Aβ40 aggregation, cerebral amyloid angiopathy |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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