Exploratory experiment designed to discover new patterns targeting LRP1 in human patients. Primary outcome: Association between LRP1 C766T polymorphism and AD susceptibility
This meta-analysis examined the association between the LRP1 C766T polymorphism (rs1799986) and Alzheimer's disease susceptibility across multiple populations. The study included 26 independent case-control studies with a total of 6,455 AD cases and 6,304 controls. The analysis investigated overall associations as well as subgroup analyses by ethnicity (Asian vs other populations) and AD onset type (late-onset vs early-onset). Multiple genetic models were tested including allele model (T vs C), dominant model (TT + CT vs CC), and recessive models. The meta-analysis aimed to resolve contradictory findings from previous individual studies regarding this polymorphism's role in AD risk.
Systematic literature review and meta-analysis of case-control studies. Studies were identified and data extracted for genotype frequencies in AD cases versus controls. Statistical analysis included calculation of odds ratios with 95% confidence intervals for different genetic models. Subgroup analyses were performed by ethnicity and AD onset type.
Clarification of the association between LRP1 C766T polymorphism and AD risk across different populations and AD subtypes
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