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clinical 1,396 words KG: PSP
Contents

LY-3372689 LOTUS Trial - Phase 2 in Progressive Supranuclear Palsy

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Knowledge Graph

Related Hypotheses (25)

Aquaporin-4 Polarization Rescue
Score: 0.73Microglial Purinergic Reprogramming
Score: 0.70Complement C1q Subtype Switching
Score: 0.66Glial Glycocalyx Remodeling Therapy
Score: 0.65Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64Sphingolipid Metabolism Reprogramming
Score: 0.62Netrin-1 Gradient Restoration
Score: 0.59Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74Phase-Separated Organelle Targeting
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Stress Granule Phase Separation Modulators
Score: 0.72Noradrenergic-Tau Propagation Blockade
Score: 0.71Lysosomal Enzyme Trafficking Correction
Score: 0.71Lysosomal Calcium Channel Modulation Therapy
Score: 0.70Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
pg 1/2Next →

Related Analyses (6)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed

Related Experiments (26)

Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40PSP and CBS Biomarker Validation Study
clinical · proposed · Score: 0.40Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40Tau Pathology Initiation Zone Identification
clinical · proposed · Score: 0.40Tau Spreading Network Mapping via Spatial Transcriptomics in
clinical · proposed · Score: 0.40

See Also (11)

Amyotrophic Lateral Sclerosis
redirect · KG edge: expressed_inFrontotemporal Dementia (FTD)
disease · KG edge: associated_withApoptosis in Neurodegeneration
entity · KG edge: associated_withAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: therapeutic_targetGenes
index · KG edge: activates

Knowledge Graph (12 edges)

DUSP10 associated_with PSP
MAP1S associated_with PSP
PSP associated_with SP1
PSP associated_with APOE
PSP associated_with TAU
PSP associated_with KIF13A
PSP associated_with TRIM24
PSP associated_with STX6
PSP associated_with MAPT
TAU activates PSP

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