biomarker 1,963 words KG: NEURODEGENERATION
Contents

MicroRNA (miRNA) Biomarkers in Neurodegenerative Disease

🔬 Protein Info
Gene SymbolNEURODEGENERATION
Aliasesneurodegeneration
Aβ/tau pathologyDownregulation of neuronal miR-9, miR-29 family members
α-Synuclein aggregationmiR-7, miR-153 target SNCA mRNA and regulate translation
NeuroinflammationmiR-155, miR-146a upregulated in activated microglia via NF-κB pathway
Mitochondrial dysfunctionmiR-30 family downregulated in PD affects mitochondrial biogenesis
TDP-43 pathologymiR-9, miR-132 dysregulation in ALS/FTD
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
Known Drugs/CompoundsCANAGLIFLOZIN, Cgmp, DPP-4 INHIBITORS, LITHIUM, MELATONIN, MEMANTINE
Interactions6-OHDA, ABCA1, ABCD1, ACE, ACE2, ACETYL-COA
KG Connections6186 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

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Related Hypotheses (142)

SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Netrin-1 Gradient Restoration
Score: 0.59
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Lysosomal Membrane Repair Enhancement
Score: 0.54
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Cryptic Exon Silencing Restoration
Score: 0.53
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
Piezoelectric Nanochannel BBB Disruption
Score: 0.52
Vocal Cord Neuroplasticity Stimulation
Score: 0.52
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
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Related Analyses (30)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

CDK5 associated_with NEURODEGENERATION
MICROGLIA enhances NEURODEGENERATION
STROKE associated_with NEURODEGENERATION
NLRP3 INFLAMMASOME associated_with NEURODEGENERATION
NEURODEGENERATION associated_with ROS
NEURODEGENERATION associated_with HUNTINGTIN
ABCA1 associated_with NEURODEGENERATION
MCOLN1 associated_with NEURODEGENERATION
GFAP associated_with NEURODEGENERATION
CD38 associated_with NEURODEGENERATION

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