biomarker 1,963 words KG: NEURODEGENERATION
Contents

MicroRNA (miRNA) Biomarkers in Neurodegenerative Disease

🔬 Protein Info
Gene SymbolNEURODEGENERATION
Aliasesneurodegeneration
Aβ/tau pathologyDownregulation of neuronal miR-9, miR-29 family members
α-Synuclein aggregationmiR-7, miR-153 target SNCA mRNA and regulate translation
NeuroinflammationmiR-155, miR-146a upregulated in activated microglia via NF-κB pathway
Mitochondrial dysfunctionmiR-30 family downregulated in PD affects mitochondrial biogenesis
TDP-43 pathologymiR-9, miR-132 dysregulation in ALS/FTD
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
Known Drugs/CompoundsCANAGLIFLOZIN, Cgmp, DPP-4 INHIBITORS, LITHIUM, MELATONIN, MEMANTINE
Interactions6-OHDA, ABCA1, ABCD1, ACE, ACE2, ACETYL-COA
KG Connections6186 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

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Related Hypotheses (142)

Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Purinergic Signaling Polarization Control
Score: 0.71
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Noradrenergic-Tau Propagation Blockade
Score: 0.71
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Membrane Cholesterol Gradient Modulators
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
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Related Analyses (30)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

MICROGLIA targets NEURODEGENERATION
NEURODEGENERATION associated_with TAU
NEURODEGENERATION associated_with AKT
NEURODEGENERATION associated_with Dementia
NEURODEGENERATION associated_with Akt
NEURODEGENERATION associated_with Mapk
NEURODEGENERATIVE DISEASES associated_with NEURODEGENERATION
NEURODEGENERATION associated_with Cardiovascular
CANCER targets NEURODEGENERATION
AUTOPHAGY targets NEURODEGENERATION

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