biomarker 1,963 words KG: NEURODEGENERATION
Contents

MicroRNA (miRNA) Biomarkers in Neurodegenerative Disease

🔬 Protein Info
Gene SymbolNEURODEGENERATION
Aliasesneurodegeneration
Aβ/tau pathologyDownregulation of neuronal miR-9, miR-29 family members
α-Synuclein aggregationmiR-7, miR-153 target SNCA mRNA and regulate translation
NeuroinflammationmiR-155, miR-146a upregulated in activated microglia via NF-κB pathway
Mitochondrial dysfunctionmiR-30 family downregulated in PD affects mitochondrial biogenesis
TDP-43 pathologymiR-9, miR-132 dysregulation in ALS/FTD
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
Known Drugs/CompoundsCANAGLIFLOZIN, Cgmp, DPP-4 INHIBITORS, LITHIUM, MELATONIN, MEMANTINE
Interactions6-OHDA, ABCA1, ABCD1, ACE, ACE2, ACETYL-COA
KG Connections6186 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

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Related Hypotheses (142)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
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Related Analyses (30)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

NEURODEGENERATIVE DISEASES associated_with NEURODEGENERATION
NEURODEGENERATION associated_with Cardiovascular
CANCER targets NEURODEGENERATION
AUTOPHAGY targets NEURODEGENERATION
AKT targets NEURODEGENERATION
ALS targets NEURODEGENERATION
DRP1 targets NEURODEGENERATION
NEURODEGENERATION targets CD33
NEURODEGENERATION targets APOPTOSIS
NEURODEGENERATION targets OXIDATIVE STRESS

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