Contents

APP Protein

🔬 Protein Info

Gene Symbol	APP
Full Name	Amyloid Precursor Protein
Chromosome	21q21.3
Protein Type	Protein
Function	is a type I transmembrane glycoprotein that plays a central role in the pathogenesis of Alzheimer's disease (AD).
Primary Expression	Ubiquitous, highest in brain
Molecular Weight	~110 kDa
Exons	18
Pathways	Amyloid, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P05067
NCBI Gene ID	351
Ensembl ID	ENSG00000142192
OMIM	104760
GeneCards	APP
Human Protein Atlas	APP
Associated Diseases	AD, aging, Als, Alzheimer
Known Drugs/Compounds	Abeta, aducanumab, Atractylodes macrocephala, berberine, BERBERINE, D-520
Interactions	A2M, ABCA1, ABCA7, ACETYLCHOLINE, ACHE, ACSL4
SciDEX Hypotheses	Selective Cholinergic Protection via APP Pathway M
KG Connections	4400 knowledge graph edges
Databases	GeneCards HPA STRING

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