Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALDH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ALDH |
| GeneCards | ALDH |
| Human Protein Atlas | ALDH |
| Associated Diseases | AND |
| Interactions | AHR, DEPRESSION, NEUROINFLAMMATION, Rb |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ALDH["ALDH"] -->|"encodes"| indole_3_lactic_acid["indole-3-lactic acid"]
style indole_3_lactic_acid fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
ALDH["ALDH"] -->|"activates"| Als["Als"]
style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ALDH["ALDH"] -->|"activates"| Depression["Depression"]
style Depression fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ALDH["ALDH"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
style Neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ALDH["ALDH"] -->|"activates"| Inflammation["Inflammation"]
style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ALDH["ALDH"] -->|"associated"| AND["AND"]
style AND fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
ALDH["ALDH"] -->|"activates"| AHR["AHR"]
style AHR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
DEPRESSION["DEPRESSION"] -->|"activates"| ALDH["ALDH"]
style DEPRESSION fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
AHR_1["AHR"] -->|"activates"| ALDH["ALDH"]
style AHR_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| ALDH["ALDH"]
style NEUROINFLAMMATION fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style ALDH fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| indole-3-lactic acid | encodes | protein | 0.90 |
| Als | activates | disease | 0.65 |
| Depression | activates | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| DEPRESSION | activates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| AHR | activates | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DEPRESSION | activates | gene | 0.60 |
| AHR | activates | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ALDH in their description or question text
No additional research found