Contents

TFEB

🧬 Gene Info

Gene Symbol	TFEB
Aliases	Transcription Factor EB
Protein Type	Transcription Factor
Target Class	Protein
Function	TFEB is constitutively expressed in most cell types, with highest expression in tissues with high lysosomal activity including:
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Primary Expression	most cell types, with highest expression in tissues with high lysosomal activity including:
Subcellular Localization	and transcriptional activity. Dysregulation of TFEB contributes to impaired protein clearance and accumulation of toxic
Druggability	Undruggable (0.23)
Molecular Weight	53 kDa
Pathways	mTOR
GeneCards	TFEB
Human Protein Atlas	TFEB
Associated Diseases	aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	bortezomib, curcumin, CURCUMIN, digoxin, ELTROMBOPAG, hederagenin
Interactions	ABCA1, ACAT1, ACETYL-COA, ACHE, ACOD1, ACOX1
SciDEX Target	View Target Profile
SciDEX Hypotheses	Cell-Type Specific TFEB Modulation The Mitochondrial-Lysosomal Metabolic Coupling Dys Radiation drives pericyte senescence through lysos (+4 more)
KG Connections	3007 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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