| Gene Symbol | SIRT6 |
| Chromosome | 19p13.3<br> |
| Protein Type | Epigenetic Regulator |
| Target Class | Epigenetic Regulator |
| Function | SIRT6 exhibits multiple enzymatic activities |
| Mechanism of Action | Small molecule activation or inhibition of NAD+-dependent deacetylase activity |
| Primary Expression | most tissues: - Brain: cortex, hippocampus, cerebellum - Substantia nigra - Low expression but |
| Druggability | Low (0.41) |
| Clinical Stage | Phase I |
| Molecular Weight | 36 kDa |
| Pathways | NF-κB |
| UniProt ID | Q9Y5W5 |
| NCBI Gene ID | 51588 |
| Ensembl ID | ENSG00000173120 |
| GeneCards | SIRT6 |
| Human Protein Atlas | SIRT6 |
| Associated Diseases | aging, Als, Alzheimer |
| Known Drugs/Compounds | nicotinamide, rapamycin, Withaferin A |
| Interactions | ABCA1, AD, AKT, AMPK, AND, App |
| SciDEX Target | View Target Profile (1 clinical trials) |
| SciDEX Hypotheses | SIRT6-NAD+ Axis Enhancement Therapy |
| KG Connections | 495 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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