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🎯 Drug Targets

Browse 11 drug targets with druggability analysis, composite scores, and clinical context

11
Targets
0
High Druggability
0.33
Avg Score
15
Target Classes
Druggability Distribution
High: 0Medium: 0Low: 0Unknown: 0
Avg druggability score: 0.225
Clinical Pipeline
Approved: 0Phase III: 0Phase II: 0Phase I: 0Preclinical: 11
Total compounds: 15 · Approved: 0
Class All Classes Enzyme (35) Signaling Protein (25) Structural Protein (17) Protein (16) Gpcr (13) Ion Channel (12) Receptor (11) Transcription Factor (11) Ligand (10) Epigenetic Regulator (8) Transporter (8) Kinase (7) Other (4) Protease (4) Chaperone (4)
Druggability All Druggability Low (97) Medium (56) Undruggable (19) High (10) other (3)
Sort Score Druggability Gene A-Z Market Price
Filtered by: class=protein, druggability=Undruggable — 11 results
CHRNA7 CHRNA7 Protein
Protein Undruggable Druggability
Score
0.39
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
15
Prioritized from 1 SciDEX hypotheses, including: Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication
OCT4 OCT4 Protein
Protein Undruggable Druggability
Score
0.36
Drug.
0.23
Safety
0.50
Drugs
1
Hyps
1
Papers
23
Prioritized from 1 SciDEX hypotheses, including: Partial Neuronal Reprogramming via Modified Yamanaka Cocktail
C4B C4B Protein
Protein Undruggable Druggability
Score
0.34
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
13
Prioritized from 1 SciDEX hypotheses, including: Age-Dependent Complement C4b Upregulation Drives Synaptic Vulnerability in Hippocampal CA1 Neurons
PHB2 PHB2 Protein
Protein Undruggable Druggability
Score
0.34
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
9
Prioritized from 1 SciDEX hypotheses, including: Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
RHOT1 RHOT1 Protein
Protein Undruggable Druggability
Score
0.34
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
8
Prioritized from 1 SciDEX hypotheses, including: Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
TFEB TFEB Protein
Protein Undruggable Druggability
Score
0.34
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
12
Prioritized from 1 SciDEX hypotheses, including: The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
DNAJB6 DNAJB6 Protein
Protein Undruggable Druggability
Score
0.33
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
8
Prioritized from 1 SciDEX hypotheses, including: HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
NURR1 NURR1 Protein
Protein Undruggable Druggability
Score
0.31
Drug.
0.23
Safety
0.50
Drugs
1
Hyps
1
Papers
7
Prioritized from 1 SciDEX hypotheses, including: Programmable Neuronal Circuit Repair via Epigenetic CRISPR
SPTLC1 SPTLC1 Protein
Protein Undruggable Druggability
Score
0.31
Drug.
0.23
Safety
0.50
Drugs
3
Hyps
1
Papers
6
Prioritized from 1 SciDEX hypotheses, including: APOE-Mediated Synaptic Lipid Raft Stabilization
AGER AGER Protein
Protein Undruggable Druggability
Score
0.30
Drug.
0.23
Safety
0.50
Drugs
10
Hyps
1
Papers
7
Prioritized from 1 SciDEX hypotheses, including: Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade
PGC1A PGC1A Protein
Protein Undruggable Druggability
Score
0.28
Drug.
0.23
Safety
0.50
Drugs
0
Hyps
1
Papers
7
Prioritized from 1 SciDEX hypotheses, including: Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Circuits
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