Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MIR-519A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MIR-519A |
| Key Genes/Proteins | APOPTOSIS, AUTOPHAGY, BCL-2, BCL2, GBM, GLIOBLASTOMA |
| Related Diseases | Glioblastoma, Glioma, Tumor |
| Related Pathways | Apoptosis, Autophagy, Chemoresistance |
graph TD
MIR_519A["MIR-519A"]
MIR_519A -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
MIR_519A -->|"inhibits"| BCL_2["BCL-2"]
MIR_519A -->|"regulates"| STAT3["STAT3"]
MIR_519A -->|"activates"| autophagy["autophagy"]
MIR_519A -.protects against.-> glioblastoma["glioblastoma"]
MIR_519A -->|"regulates"| temozolomide["temozolomide"]
MIR_519A -->|"activates"| apoptosis["apoptosis"]
temozolomide -->|"regulates"| MIR_519A
APOPTOSIS["APOPTOSIS"] -->|"activates"| MIR_519A
STAT3 -->|"activates"| MIR_519A| Target | Relation | Type | Str |
|---|---|---|---|
| BCL-2 | inhibits | gene | 0.80 |
| autophagy | activates | process | 0.70 |
| temozolomide | regulates | drug | 0.70 |
| STAT3 | regulates | protein | 0.70 |
| STAT3 | inhibits | protein | 0.70 |
| glioblastoma | protects_against | disease | 0.70 |
| apoptosis | activates | process | 0.70 |
| Glioblastoma | activates | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Glioma | activates | disease | 0.65 |
| Autophagy | activates | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Chemoresistance | activates | pathway | 0.60 |
| GBM | therapeutic_target | gene | 0.60 |
| BCL2 | activates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| BCL-2 | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| GLIOBLASTOMA | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| temozolomide | regulates | drug | 0.70 |
| temozolomide | activates | drug | 0.70 |
| APOPTOSIS | activates | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MIR-519A in their description or question text
No additional research found