gene

TRPM3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPM3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

4Outgoing

6Incoming

0Experiments

0Debates

Summary

Page for TRPM3 Gene - Transient Receptor Potential Channel

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🧬 Gene Info

Gene Symbol	TRPM3
Aliases	Page for TRPM3 Gene
Chromosome	9q21.11
Protein Family	TRPM (Transient Receptor Potential Melastatin)
Protein Type	Channel
Function	encodes a calcium-permeable nonselective cation channel belonging to the TRPM (Transient Receptor Potential Melastatin) family.
Primary Expression	the central nervous system, with particularly high expression in regions involved in temperature sensation and endocrine function
Molecular Weight	168 kDa
Pathways	Akt
UniProt ID	Q9BQY4
NCBI Gene ID	80084
Ensembl ID	ENSG00000083099
OMIM	608394
GeneCards	TRPM3
Human Protein Atlas	TRPM3
Associated Diseases	neurodegeneration
Interactions	SRC, TRPA1
KG Connections	10 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRPM3 — AlphaFold Q9BQY4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TRPM3 Gene - Transient Receptor Potential Channel

gene · 1640 words

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TRPM3 Protein

protein · 1134 words

→

Pathway Diagram

graph TD
    TRPM3["TRPM3"]
    Ms{"Ms"}
    TRPM3 -->|"inhibits"| Ms
    Migraine{"Migraine"}
    TRPM3 -->|"inhibits"| Migraine
    CREBBP["CREBBP"]
    TRPM3 -->|"regulates"| CREBBP
    Akt(["Akt"])
    TRPM3 -->|"regulates"| Akt
    neurodegeneration["neurodegeneration"]
    TRPM3 -->|"implicated in"| neurodegeneration
    TRPA1["TRPA1"]
    TRPA1 -->|"inhibits"| TRPM3
    SRC["SRC"]
    SRC -->|"inhibits"| TRPM3
    SCN8A["SCN8A"]
    SCN8A -->|"regulates"| TRPM3
    AKT1["AKT1"]
    AKT1 -->|"regulates"| TRPM3
    style TRPM3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Ms	inhibits	disease	0.65
Migraine	inhibits	disease	0.65
CREBBP	regulates	gene	0.60
Akt	regulates	pathway	0.60

Incoming (6)

Source	Relation	Type	Str
genes-trpm3	linked_to	wiki_page	1.00
TRPA1	inhibits	gene	0.60
SRC	inhibits	gene	0.60
SCN8A	regulates	gene	0.60
AKT1	regulates	gene	0.60
TRPM2	implicated_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRPM3 in their description or question text

No additional research found