gene

LAMA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAMA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

12Outgoing

3Incoming

0Experiments

0Debates

Summary

LAMA2 encodes laminin alpha-2, a critical extracellular matrix protein in skeletal muscle, peripheral nerve, and brain. Mutations cause congenital muscular dystrophy and merosin-deficient muscular dystrophy.

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🧬 Gene Info

Gene Symbol	LAMA2
Full Name	Laminin Subunit Alpha 2
Chromosome	6q22.33
Function	LAMA2 (Laminin Subunit Alpha 2) encodes the laminin alpha-2 chain, a critical component of the extracellular matrix
Primary Expression	Skeletal Muscle, Peripheral Nerve, Brain
Amino Acids	128 aa
Pathways	Apoptosis
UniProt ID	P24071
NCBI Gene ID	3908
Ensembl ID	ENSG00000196559
OMIM	156225
GeneCards	LAMA2
Human Protein Atlas	LAMA2
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LAMA2 — AlphaFold P24071 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LAMA2 — Laminin Subunit Alpha 2

gene · 1707 words

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Pathway Diagram

graph TD
    LAMA2["LAMA2"]
    Heart_Failure{"Heart Failure"}
    LAMA2 -->|"therapeutic target"| Heart_Failure
    Ms{"Ms"}
    LAMA2 -->|"therapeutic target"| Ms
    LAMA2 -->|"regulates"| Ms
    PLN["PLN"]
    LAMA2 -->|"therapeutic target"| PLN
    TPM1["TPM1"]
    LAMA2 -->|"therapeutic target"| TPM1
    GENE_MUTATIONS["GENE MUTATIONS"]
    LAMA2 -->|"therapeutic target"| GENE_MUTATIONS
    LMNA["LMNA"]
    LAMA2 -->|"therapeutic target"| LMNA
    ATF4["ATF4"]
    LAMA2 -->|"therapeutic target"| ATF4
    BCL2L13["BCL2L13"]
    LAMA2 -->|"regulates"| BCL2L13
    NF2["NF2"]
    LAMA2 -->|"regulates"| NF2
    APOPTOSIS["APOPTOSIS"]
    LAMA2 -->|"regulates"| APOPTOSIS
    Apoptosis(["Apoptosis"])
    LAMA2 -->|"regulates"| Apoptosis
    PHGDH["PHGDH"]
    PHGDH -->|"therapeutic target"| LAMA2
    style LAMA2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
Heart Failure	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
GENE MUTATIONS	therapeutic_target	gene	0.60
APOPTOSIS	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
PLN	therapeutic_target	gene	0.60
TPM1	therapeutic_target	gene	0.60
LMNA	therapeutic_target	gene	0.60
ATF4	therapeutic_target	gene	0.60
BCL2L13	regulates	gene	0.60
NF2	regulates	gene	0.60

Incoming (3)

Source	Relation	Type	Str
genes-lama2	linked_to	wiki	1.00
genes-lama2	describes	wiki	0.90
PHGDH	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LAMA2 in their description or question text

No additional research found