gene

KCNB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

6Outgoing

6Incoming

0Experiments

0Debates

Summary

KCNB1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, inhibits. Associated with Aging, Ms. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KCNB1
Full Name	Potassium Voltage-Gated Channel Subfamily B Member 1
Chromosome	20q13.13
Pathways	Immune Response
UniProt ID	Q14721
NCBI Gene ID	3745
Ensembl ID	ENSG00000158445
GeneCards	KCNB1
Human Protein Atlas	KCNB1
Oxidative injury coupling	Experimental models show that oxidized Kv2.1 species can promote neuronal dysfunction and cognitive deficits.[@cotella2019][@boscia2016]
Excitability dysregulation	Perturbed delayed-rectifier currents can shift neurons toward calcium overload and stress-sensitive phenotypes.[@misonou2005][@misonou2005a]
Associated Diseases	neurodegeneration
Interactions	KCNG2, KCNV2, OXIDATIVE STRESS, STAT3
KG Connections	12 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNB1 — AlphaFold Q14721 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCNB1 Gene

gene · 649 words

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Pathway Diagram

graph TD
    KCNB1["KCNB1"]
    Aging{"Aging"}
    KCNB1 -->|"regulates"| Aging
    Ms{"Ms"}
    KCNB1 -->|"regulates"| Ms
    STAT3["STAT3"]
    KCNB1 -->|"activates"| STAT3
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    KCNB1 -->|"activates"| OXIDATIVE_STRESS
    Oxidative_Stress(["Oxidative Stress"])
    KCNB1 -->|"activates"| Oxidative_Stress
    Immune_Response(["Immune Response"])
    KCNB1 -->|"regulates"| Immune_Response
    neurodegeneration["neurodegeneration"]
    KCNB1 -->|"implicated in"| neurodegeneration
    BMP_2["BMP-2"]
    BMP_2 -->|"upregulates"| KCNB1
    KCNG2["KCNG2"]
    KCNG2 -->|"inhibits"| KCNB1
    KCNV2["KCNV2"]
    KCNV2 -->|"inhibits"| KCNB1
    AGING["AGING"]
    AGING -->|"regulates"| KCNB1
    SOCS3["SOCS3"]
    SOCS3 -->|"regulates"| KCNB1
    style KCNB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Aging	regulates	disease	0.65
Ms	regulates	disease	0.65
OXIDATIVE STRESS	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Immune Response	regulates	pathway	0.60
STAT3	activates	gene	0.60

Incoming (6)

Source	Relation	Type	Str
genes-kcnb1	linked_to	wiki	1.00
BMP-2	upregulates	protein	0.70
KCNG2	inhibits	gene	0.70
KCNV2	inhibits	gene	0.70
SOCS3	regulates	gene	0.60
AGING	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNB1 in their description or question text

No additional research found