gene

KCNV2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNV2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

1Outgoing

0Incoming

0Experiments

0Debates

Summary

KCNV2 Gene

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🧬 Gene Info

Gene Symbol	Potassium Voltage-Gated Channel Modifier Subfamily V Member 2
Chromosome	9p24.2
Protein Type	Channel
Function	KCNV2 encodes a voltage-gated potassium channel regulatory subunit that modulates the function of diverse potassium channel complexes.
UniProt ID	Q9EQB4
NCBI Gene ID	169165
Ensembl ID	ENSG00000168243
OMIM	607355
Channel modulation	KCNV2 alters voltage-dependence and kinetics of Kv channel gating
Surface expression	Facilitates proper trafficking and membrane localization of channel complexes
Retinal function	Critical for normal photoreceptor electrophysiology and survival
Neural excitability	Modulates neuronal firing patterns in various brain regions
Night Blindness (Congenital Stationary)	KCNV2 mutations can cause non-progressive night blindness without cone dystrophy in some cases [2].
Retinal degeneration	Loss of KCNV2 function leads to photoreceptor degeneration through mechanisms including calcium dysregulation and metabolic stress.
Retina	High expression in cone and rod photoreceptors of the outer nuclear layer
Associated Diseases	neurodegeneration
Interactions	KCNB1
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNV2 — AlphaFold Q9EQB4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCNV2 Gene

gene · 537 words

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Pathway Diagram

graph TD
    KCNV2["KCNV2 gene"]
    KCNB1["KCNB1 gene"]
    Kv2_1["Kv2.1 channel protein"]
    KvS["Kv channel subunit"]
    K_current["Delayed rectifier K+ current"]
    Membrane_pot["Neuronal membrane potential"]
    Ca_influx["Calcium influx"]
    Excitotoxicity["Excitotoxicity"]
    Neuronal_death["Neuronal cell death"]
    Synaptic_dysfunction["Synaptic dysfunction"]
    Neurodegeneration["Neurodegeneration"]
    Neuroprotection["Neuroprotective mechanisms"]
    Ion_homeostasis["Ion homeostasis"]
    Action_potential["Action potential regulation"]
    Voltage_sensing["Voltage sensing"]
    
    KCNV2 -->|"inhibits"| KCNB1
    KCNV2 -->|"encodes"| KvS
    KCNB1 -->|"encodes"| Kv2_1
    KvS -->|"modulates"| Kv2_1
    Kv2_1 -->|"conducts"| K_current
    K_current -->|"regulates"| Membrane_pot
    K_current -->|"controls"| Action_potential
    Membrane_pot -->|"affects"| Ca_influx
    Ca_influx -->|"triggers"| Excitotoxicity
    Excitotoxicity -->|"causes"| Neuronal_death
    Neuronal_death -->|"leads to"| Neurodegeneration
    K_current -->|"maintains"| Ion_homeostasis
    Ion_homeostasis -->|"supports"| Neuroprotection
    Kv2_1 -->|"dysfunction causes"| Synaptic_dysfunction
    Synaptic_dysfunction -->|"contributes to"| Neurodegeneration
    
    style KCNV2 fill:#1a3a4a,stroke:#4fc3f7
    style Neuroprotection fill:#1a3a2a,stroke:#81c784
    style Ion_homeostasis fill:#1a3a2a,stroke:#81c784
    style Excitotoxicity fill:#3a1a1a,stroke:#ef5350
    style Neuronal_death fill:#3a1a1a,stroke:#ef5350
    style Neurodegeneration fill:#3a2a1a,stroke:#ffa726
    style Synaptic_dysfunction fill:#3a1a1a,stroke:#ef5350
    style KCNB1 fill:#2a1a3a,stroke:#ce93d8
    style Kv2_1 fill:#2a1a3a,stroke:#ce93d8

Outgoing (1)

Target	Relation	Type	Str
KCNB1	inhibits	gene	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNV2 in their description or question text

No additional research found