therapeutic

edaravone

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about edaravone: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

1Analyses

30Outgoing

13Incoming

0Experiments

1Debates

Summary

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💊 Therapeutic Info

Name	edaravone
Related Diseases	ALS, Amyotrophic Lateral Sclerosis
Related Pathways	Oxidative Damage

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

edaravone

therapeutic · 1852 words

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Pathway Diagram

flowchart TD
    edaravone["edaravone"]
    Oxidative_Stress["Oxidative Stress"]
    edaravone -->|"inhibits"| Oxidative_Stress
    Oxidative_Damage("Oxidative Damage")
    edaravone -->|"associated with"| Oxidative_Damage
    Amyotrophic_Lateral_Sclerosis("Amyotrophic Lateral Sclerosis")
    edaravone -->|"treats"| Amyotrophic_Lateral_Sclerosis
    Mitochondrial_Function["Mitochondrial Function"]
    edaravone -->|"associated with"| Mitochondrial_Function
    Neuroinflammation("Neuroinflammation")
    edaravone -->|"modulates"| Neuroinflammation
    ALS("ALS")
    edaravone -->|"treats"| ALS

    style edaravone fill:#0d47a1,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (30)

Target	Relation	Type	Str
Oxidative Stress	inhibits	process	0.90
Oxidative Damage	associated_with	mechanism	0.90
Neuroinflammation	modulates	process	0.80
Amyotrophic Lateral Sclerosis	treats	disease	0.80
Mitochondrial Function	associated_with	process	0.80
OXIDATIVE_STRESS	treats	process	0.78
NEURON	activates	cell_type	0.70
APP	treats	gene	0.65
OLIGODENDROCYTE	degrades	cell_type	0.65
SIRT1	treats	gene	0.65
NEURON	associated_with	cell_type	0.50
ALS	therapeutic_target_for	disease	0.50
GLUTAMATE	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
ALS	associated_with	disease	0.45
MINOCYCLINE	associated_with	drug	0.45
MAPK	associated_with	gene	0.45
STROKE	associated_with	disease	0.45
RILUZOLE	associated_with	drug	0.45
SOD1	associated_with	gene	0.45
TREM2	associated_with	gene	0.45
TLR4	associated_with	gene	0.45
APP	associated_with	gene	0.45
KEAP1	associated_with	gene	0.45
SIRT1	associated_with	gene	0.45
NRF2	associated_with	gene	0.45
GPX4	associated_with	gene	0.45
MBP	associated_with	gene	0.45
RILUZOLE	therapeutic_target	drug	0.35
MINOCYCLINE	inhibits	drug	0.35

Incoming (13)

Source	Relation	Type	Str
28400812	reduces	paper	0.90
28400812	inhibits activation of	paper	0.90
28400812	reduces expression of	paper	0.90
ALS	treats	disease	0.65
28400812	prevents	paper	0.60
ALS	associated_with	disease	0.45
MINOCYCLINE	associated_with	drug	0.45
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45
NEUROGENESIS	associated_with	phenotype	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
OLIGODENDROCYTE	associated_with	cell_type	0.45
CYTOKINES	inhibits	protein	0.35
ALS	therapeutic_target	disease	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Oxidative Stress Upstream of TDP-43 Mislocalization in ALS Motor Neurons

neurodegeneration | 2026-04-27 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can targeting oxidative stress pathways (NRF2, SOD1, mitochondrial ROS) upstream

active · Rounds: 6 · Score: 0.62 · 2026-04-27

Related Research

Hypotheses and analyses mentioning edaravone in their description or question text

No additional research found