gene

ank1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ank1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

29Outgoing

9Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ANK1
Full Name	Ankyrin 1
Function	Ankyrin 1 is a membrane-associated protein that serves as a critical anchor between the plasma membrane and the underlying cytoskeleton.
Primary Expression	Substantia Nigra
Molecular Weight	210 kDa
Pathways	Alpha-Synuclein
Ensembl ID	ENSG00000162678
GeneCards	ANK1
Human Protein Atlas	ANK1
Cytoskeletal Linkage	ANK1 links integral membrane proteins to the spectrin-actin skeleton, providing structural stability to neuronal membranes.
Axonal Transport	The ankyrin-spectrin skeleton facilitates axonal transport by providing tracks for motor proteins and maintaining cargo organization.
Glial Function	In astrocytes, ANK1 helps organize water channels (AQP4) and Kir4.1 potassium channels at perivascular endfeet, crucial for blood-brain barrier function and potassium buffering.
Membrane Integrity	ANK1 variants may affect neuronal membrane stability, making neurons more vulnerable to amyloid-beta (Aβ) toxicity.
Synaptic Function	ANK1 is involved in organizing postsynaptic receptor complexes, and dysregulation may contribute to synaptic dysfunction in AD.
Astrocyte Reactivity	ANK1 expression is altered in reactive astrocytes surrounding amyloid plaques, suggesting a role in neuroinflammation.
Associated Diseases	Alzheimer, Parkinson
KG Connections	31 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ANK1["ANK1"]
    ANK1 -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
    ANK1 -->|"expressed in"| Als["Als"]
    ANK1 -->|"expressed in"| ALS["ALS"]
    ANK1 -->|"expressed in"| SNCA["SNCA"]
    ANK1 -->|"expressed in"| Neuron["Neuron"]
    ANK1 -->|"expressed in"| IFN__["IFN-Gamma"]
    ANK1 -->|"expressed in"| ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ANK1 -->|"expressed in"| Alpha_Synuclein["Alpha-Synuclein"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| ANK1
    SNCA -->|"expressed in"| ANK1
    IFN["IFN"] -->|"expressed in"| ANK1

Outgoing (29)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ANK1	data_in	dataset_row	0.00
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
PARKINSON	associated_with	gene	0.60
Neuron	expressed_in	cell_type	0.60
ALZHEIMER	associated_with	gene	0.60
Parkinson's disease	expressed_in	disease	0.60
Alzheimer's disease	expressed_in	disease	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
IFN-Γ	expressed_in	gene	0.60
ALPHA-SYNUCLEIN	expressed_in	gene	0.60
Alpha-Synuclein	expressed_in	pathway	0.60
Α-Synuclein	expressed_in	protein	0.60
RIT2	expressed_in	gene	0.60
Interferon	expressed_in	protein	0.60
RIT2	associated_with	gene	0.60
SNCA	expressed_in	gene	0.60
Ras	expressed_in	protein	0.60
Substantia Nigra	expressed_in	brain_region	0.55
Parkinson's Disease	expressed_in	disease	0.50
disease	expressed_in	disease	0.50
RIT2	expressed_in	gene	0.50
PARKINSON'S	expressed_in	concept	0.50
ALZHEIMER'S	expressed_in	concept	0.50
ALZHEIMER	expressed_in	gene	0.50
PARKINSON	expressed_in	gene	0.50

Incoming (9)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ANK1	data_in	dataset_row	0.00
RIT2	associated_with	gene	0.60
SNCA	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	associated_with	gene	0.60
IFN	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ank1 in their description or question text

No additional research found