concept

WNT SIGNALING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT SIGNALING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

7Outgoing

22Incoming

0Experiments

0Debates

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💡 Concept Info

Name	WNT SIGNALING PATHWAY

Pathway Diagram

graph TD
    WNT_SIGNALING_PATHWAY["WNT SIGNALING PATHWAY"]
    WNT_SIGNALING_PATHWAY -->|"activates"| HIF_1_["HIF-1alpha"]
    WNT_SIGNALING_PATHWAY -->|"regulates"| MYC["MYC"]
    WNT_SIGNALING_PATHWAY -->|"contributes to"| High_Risk_Ovarian_Cancer["High-Risk Ovarian Cancer"]
    WNT_SIGNALING_PATHWAY -->|"regulates"| Ischemia_reperfusion_injury["Ischemia-reperfusion injury"]
    WNT_SIGNALING_PATHWAY -->|"regulates"| tissue_damage["tissue damage"]
    WIF1["WIF1"] -->|"inhibits"| WNT_SIGNALING_PATHWAY
    NPC1["NPC1"] -->|"regulates"| WNT_SIGNALING_PATHWAY
    Cluster_1_Upregulated_Genes["Cluster 1 Upregulated Genes"] -->|"involved_in"| WNT_SIGNALING_PATHWAY
    Cluster_1_Upregulated_DEGs["Cluster 1 Upregulated DEGs"] -->|"upregulates"| WNT_SIGNALING_PATHWAY
    EPHA5["EPHA5"] -->|"activates"| WNT_SIGNALING_PATHWAY
    BAX["BAX"] -->|"regulates"| WNT_SIGNALING_PATHWAY
    BCL2["BCL2"] -->|"regulates"| WNT_SIGNALING_PATHWAY
    DKK1["DKK1"] -->|"inhibits"| WNT_SIGNALING_PATHWAY

Outgoing (7)

Target	Relation	Type	Str
AUTOPHAGY	regulates	process	0.90
HIF-1α	activates	protein	0.90
MYC	regulates	gene	0.85
Ovarian Cancer	contributes_to	disease	0.85
High-Risk Ovarian Cancer	contributes_to	phenotype	0.78
Ischemia-reperfusion injury	regulates	process	0.70
tissue damage	regulates	process	0.70

Incoming (22)

Source	Relation	Type	Str
Thermal Adaptation	inhibits	process	0.95
WIF1	inhibits	protein	0.95
NPC1	regulates	gene	0.90
40102948	affects	paper	0.90
37009120	regulates	paper	0.90
40102948	identified as most significant	paper	0.90
Cluster 1 Upregulated Genes	involved_in	biomarker	0.88
Cluster 1 Upregulated DEGs	upregulates	biomarker	0.85
EPHA5	activates	gene	0.80
BAX	regulates	gene	0.80
OPTN	associated_with	gene	0.75
mechanosensitive ion channel	regulates	protein	0.75
DKK1	inhibits	protein	0.70
LRP1	regulates	gene	0.70
Notch pathway	interacts_with	pathway	0.70
phosphatidylinositol 3-kinase/protein kinase B pathway	interacts_with	pathway	0.70
transforming growth factor-β pathway	interacts_with	pathway	0.70
bone morphogenetic protein pathway	interacts_with	pathway	0.70
BCL2	regulates	gene	0.70
24387789	is associated with	paper	0.60
40102948	was identified as	paper	0.60
40102948	identified as most significant pathway affected	paper	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WNT SIGNALING PATHWAY in their description or question text

No additional research found