Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MECHANOSENSITIVE ION CHANNEL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MECHANOSENSITIVE ION CHANNEL |
| Related Diseases | Ovarian Cancer |
graph TD
MECHANOSENSITIVE_ION_CHANNEL[MECHANOSENSITIVE ION CHANNEL]
MECHANOSENSITIVE_ION_CHANNEL -->|involved_in| Mechanotransduction[Mechanotransduction]
MECHANOSENSITIVE_ION_CHANNEL -->|involved_in| Ovarian_Cancer[Ovarian Cancer]
MECHANOSENSITIVE_ION_CHANNEL -->|involved_in| Orthodontic_Tooth_Movement[Orthodontic Tooth Movement]
MECHANOSENSITIVE_ION_CHANNEL -->|modulates| Prognosis[Prognosis]
MECHANOSENSITIVE_ION_CHANNEL -->|mediates| Patient_Risk_Stratification[Patient Risk Stratification]
MECHANOSENSITIVE_ION_CHANNEL -->|involved_in| focal_adhesion_pathway[focal adhesion pathway]
MECHANOSENSITIVE_ION_CHANNEL -->|involved_in| ECM_receptor_interaction[ECM-receptor interaction]
MECHANOSENSITIVE_ION_CHANNEL -->|regulates| Wnt_signaling_pathway[Wnt signaling pathway]
Inflammation[Inflammation] -->|modulates| MECHANOSENSITIVE_ION_CHANNEL
TNF[TNF] -->|regulates| MECHANOSENSITIVE_ION_CHANNEL
CFTR[CFTR] -->|involved_in| MECHANOSENSITIVE_ION_CHANNEL
TRPV4[TRPV4] -->|interacts| MECHANOSENSITIVE_ION_CHANNEL| Target | Relation | Type | Str |
|---|---|---|---|
| Ovarian Cancer | associated_with | disease | 0.90 |
| Mechanotransduction | involved_in | process | 0.90 |
| Ovarian Cancer | associated_with | disease | 0.90 |
| Prognosis | modulates | phenotype | 0.85 |
| Orthodontic Tooth Movement | involved_in | process | 0.85 |
| Patient Risk Stratification | mediates | process | 0.82 |
| Orthodontic Tooth Movement | targets | phenotype | 0.80 |
| focal adhesion pathway | involved_in | pathway | 0.80 |
| ECM-receptor interaction | involved_in | pathway | 0.78 |
| Wnt signaling pathway | regulates | pathway | 0.75 |
| Hippo signaling pathway | regulates | pathway | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Inflammation | modulates | process | 0.95 |
| TNF | regulates | entity | 0.92 |
| CFTR | involved_in | gene | 0.85 |
| TRPV4 | interacts_with | gene | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Mechanosensitive Ion Channel Reprogramming | 0.700 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TREK-1 regulation of conventional outflow facility in mouse eyes | validation | ocular hypertension | 0.900 | 0.00 | mouse eyes | proposed | N/A |
| DEX effects on TREK-1 currents in human primary TM cells | exploratory | corticosteroid-induced ocular | 0.900 | 0.00 | primary human trabecular meshw | proposed | N/A |
| TREK-1 effects on IOP in DEX-induced mouse OHT model | validation | dexamethasone-induced ocular h | 0.900 | 0.00 | mouse eyes | proposed | N/A |
| DEX effects on K2P channel transcriptome in mouse TM cells | exploratory | corticosteroid-induced ocular | 0.900 | 0.00 | mouse trabecular meshwork cell | proposed | N/A |
| TREK-1 effects on spontaneous OHT in rats using telemetry | validation | spontaneous ocular hypertensio | 0.800 | 0.00 | rat eyes | proposed | N/A |
| TREK-1 localization in trabecular meshwork by immunohistochemistry | exploratory | ocular hypertension | 0.800 | 0.00 | trabecular meshwork tissue | proposed | N/A |
| Proposed experiment from debate on Perivascular spaces and glymphatic | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $240,000 |
| Endocannabinoid System Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe | clinical | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $200,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Identification of mechanosensitive ion channel-related molecular subtypes and ke [PMID:40950697] | Zhang L, Wang L, Wang M, Peng K, Chen H, | Transl Cancer Res | 2025 | 1 |
| Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outf [PMID:41268978] | Redmon SN, Yarishkin O, Rudzitis CN, Lak | Invest Ophthalmol Vis Sci | 2025 | 1 |
| Inflammation alters the expression and activity of the mechanosensitive ion chan [PMID:39789885] | Ren J, Zhan C, Lin Y | Eur J Orthod | 2024 | 1 |
| Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007] | Zong B, Yu F, Zhang X, Pang Y, Zhao W, S | Ageing Res Rev | 2023 | 1 |
| Piezo-type mechanosensitive ion channel component 1: a mechano-bioenergetic tran [PMID:41437911] | ["Zhang Y", "Gao C", "Li Y", "Fu Q", "Li | Annals of medicine | 2026 | 0 |
| Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic [PMID:40653265] | ["Li R", "Xia J", "Shi C", "Zhang K", "Q | Journal of advanced research | 2026 | 0 |
| Piezo1: structural pharmacology and mechanotransduction mechanisms. [PMID:40750459] | ["Wang J", "Jing F", "Zhao Y", "You Z", | Trends in pharmacological scie | 2025 | 0 |
| Emerging roles of mechanically activated ion channels in autoimmune disease. [PMID:40194731] | ["Zeng Z", "Chen E", "Xue J"] | Autoimmunity reviews | 2025 | 0 |
| Local soft niches in mechanically heterogeneous primary tumors promote brain met [PMID:40009679] | ["Tang K", "Zheng Y", "Hu G", "Xin Y", " | Science advances | 2025 | 0 |
| Amyloid beta Aβ [PMID:39722451] | ["Lim X", "Willemse L", "Harraz O"] | Biophysical journal | 2025 | 0 |
| Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and em [PMID:41195420] | Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li | Frontiers in molecular bioscie | 2025 | 0 |
| PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy o [PMID:41051683] | Gupta T, Singh TG, Singh R | Molecular biology reports | 2025 | 0 |
| Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mi [PMID:39824919] | ["Scott K", "Tan Y", "Johnson D", "Elsaa | Nature metabolism | 2025 | 0 |
| Corticosteroids elevate intraocular pressure through suppression of TREK-1 signa [PMID:40894745] | Redmon SN, Yarishkin O, Rudzitis CN, Lak | bioRxiv : the preprint server | 2025 | 0 |
| Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow [PMID:39375369] | ["Lim X", "Abd-Alhaseeb M", "Ippolito M" | Nature communications | 2024 | 0 |
| Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid h [PMID:39436995] | ["Zhang J", "Zhao Y", "Wu S", "Han M", " | Science signaling | 2024 | 0 |
| Biophysical and mechanobiological considerations for T-cell-based immunotherapy. [PMID:37172572] | ["Zhuang C", "Gould J", "Enninful A", "S | Trends in pharmacological scie | 2023 | 0 |
| Mechanosensitive ion channel Piezo1 mediates mechanical ventilation-exacerbated [PMID:36526145] | ["Fang X", "Li M", "Wang Y", "Zhang P", | Journal of advanced research | 2023 | 0 |
| Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular [PMID:37587100] | ["Freitas-Andrade M", "Comin C", "Van Dy | Nature communications | 2023 | 0 |
| Focused ultrasound excites cortical neurons via mechanosensitive calcium accumul [PMID:35078979] | ["Yoo S", "Mittelstein D", "Hurt R", "La | Nature communications | 2022 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MECHANOSENSITIVE ION CHANNEL in their description or question text
No additional research found