gene

VKORC1L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VKORC1L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

10Outgoing

4Incoming

0Experiments

0Debates

Summary

Page for VKORC1L1 Gene - Vitamin K Epoxide Reductase Complex Subunit 1-Like 1

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🧬 Gene Info

Gene Symbol	VKORC1L1
Full Name	Vitamin K Epoxide Reductase Complex Subunit 1-Like 1
Aliases	Page for VKORC1L1 Gene
Chromosome	7q11.22
Protein Type	Reductase
Function	Vitamin K metabolism
Primary Expression	Brain, Liver, Lung, Heart
Amino Acids	373 aa
Pathways	Chemoresistance, Drug Resistance, Ferroptosis, Wnt
UniProt ID	Q8N4U2
NCBI Gene ID	89439
Ensembl ID	ENSG00000137868
GeneCards	VKORC1L1
Human Protein Atlas	VKORC1L1
Interactions	CANCER, FERROPTOSIS, MDM2, P53, ROS, SLC7A11
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VKORC1L1 — AlphaFold Q8N4U2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

VKORC1L1 Gene - Vitamin K Epoxide Reductase Complex Subunit 1-Like 1

gene · 742 words

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Pathway Diagram

graph TD
    VKORC1L1["VKORC1L1"]
    Colorectal_Cancer{"Colorectal Cancer"}
    VKORC1L1 -->|"activates"| Colorectal_Cancer
    Cancer{"Cancer"}
    VKORC1L1 -->|"activates"| Cancer
    Tumor{"Tumor"}
    VKORC1L1 -->|"activates"| Tumor
    Als{"Als"}
    VKORC1L1 -->|"activates"| Als
    MDM2(["MDM2"])
    VKORC1L1 -->|"activates"| MDM2
    CANCER(["CANCER"])
    VKORC1L1 -->|"activates"| CANCER
    SLC7A11(["SLC7A11"])
    SLC7A11 -->|"activates"| VKORC1L1
    ROS(["ROS"])
    ROS -->|"activates"| VKORC1L1
    P53(["P53"])
    P53 -->|"activates"| VKORC1L1
    FERROPTOSIS(["FERROPTOSIS"])
    FERROPTOSIS -->|"activates"| VKORC1L1
    style VKORC1L1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (10)

Target	Relation	Type	Str
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Drug Resistance	activates	pathway	0.60
MDM2	activates	gene	0.60
Chemoresistance	activates	pathway	0.60
CANCER	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
Wnt	activates	pathway	0.60

Incoming (4)

Source	Relation	Type	Str
SLC7A11	activates	gene	0.60
ROS	activates	gene	0.60
P53	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VKORC1L1 in their description or question text

No additional research found