protein

VGAT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VGAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

4Outgoing

5Incoming

0Experiments

0Debates

Summary

Page for VGAT Protein

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🔬 Protein Info

Gene Symbol	VGAT
Function	VGAT (SLC32A1), also known as VIAAT (Vesicular Inhibitory Amino Acid Transporter), is a 525-amino acid transmembrane protein that packages GABA and glycine into synaptic vesicles.
Subcellular Localization	Synaptic vesicles of GABAergic and glycinergic neurons ; Pr
Molecular Weight	57 kDa
Amino Acids	525 aa
Pathways	GABAergic signaling
GeneCards	VGAT
Human Protein Atlas	VGAT
Interactions	GABA, VACHT, VGLUT1
KG Connections	9 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    VGAT(["VGAT"])
    GABAergic_signaling["GABAergic signaling"]
    VACHT(["VACHT"])
    Hippocampus["Hippocampus"]
    GLUTAMATE("GLUTAMATE")
    acetylcholine["acetylcholine"]
    VGLUT1(["VGLUT1"])
    GABA(["GABA"])

    VGAT -->|"regulates"| GABAergic_signaling
    VGAT -.->|"inhibits"| VACHT
    VGAT -.->|"inhibits"| Hippocampus
    VGAT -.->|"inhibits"| GLUTAMATE
    acetylcholine -.->|"inhibits"| VGAT
    VGLUT1 -.->|"inhibits"| VGAT
    GABA -.->|"inhibits"| VGAT

    style VGAT fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (4)

Target	Relation	Type	Str
GABAergic signaling	regulates	pathway	0.70
VACHT	inhibits	protein	0.50
Hippocampus	inhibits	entity	0.50
GLUTAMATE	inhibits	concept	0.50

Incoming (5)

Source	Relation	Type	Str
acetylcholine	inhibits	disease	0.50
VGLUT1	inhibits	gene	0.50
GABA	inhibits	gene	0.50
ESR1	co_expressed_with	gene	0.50
GABA	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VGAT in their description or question text

No additional research found