protein

UNG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UNG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

13Outgoing

6Incoming

0Experiments

0Debates

Summary

UNG (Uracil-DNA Glycosylase) is a key base excision repair enzyme that removes uracil from DNA, preventing C→T transition mutations. Critical for neuronal genome integrity and implicated in Alzheimer's, Parkinson's, Huntington's disease, and aging.

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🔬 Protein Info

Gene Symbol	UNG
Aliases	Uracil-DNA Glycosylase
Chromosome	12q24.31
Protein Type	Enzyme
Function	is a critical DNA repair enzyme that protects the genome from uracil incorporation and deamination.
Molecular Weight	36 kDa
Amino Acids	313 aa
Exons	7
Pathways	Neurogenesis
Ensembl ID	ENSG00000166200
GeneCards	UNG
Human Protein Atlas	UNG
Associated Diseases	neurodegeneration
Interactions	DEMENTIA, DEPRESSION, NEURODEGENERATION, STROKE
KG Connections	19 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

UNG Gene

gene · 1801 words

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UNG Protein

protein · 1286 words

→

Pathway Diagram

graph TD
    UNG["UNG"]
    SDHB["SDHB"]
    UNG -->|"associated with"| SDHB
    Dna_Methylation(["Dna Methylation"])
    UNG -->|"associated with"| Dna_Methylation
    Complement(["Complement"])
    UNG -->|"associated with"| Complement
    neurodegeneration["neurodegeneration"]
    UNG -->|"implicated in"| neurodegeneration
    STX17["STX17"]
    STX17 -->|"associated with"| UNG
    ATP5MC1["ATP5MC1"]
    ATP5MC1 -->|"associated with"| UNG
    TXNRD1["TXNRD1"]
    TXNRD1 -->|"associated with"| UNG
    MFN2["MFN2"]
    MFN2 -->|"associated with"| UNG
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    MITOCHONDRIAL_DYSFUNCTION -->|"associated with"| UNG
    style UNG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

Target	Relation	Type	Str
Depression	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Dementia	activates	disease	0.65
Als	inhibits	disease	0.65
Stroke	activates	disease	0.65
STROKE	activates	gene	0.60
SDHB	associated_with	gene	0.60
DNA	regulates	gene	0.60
DEPRESSION	activates	gene	0.60
DEMENTIA	activates	gene	0.60
Neurogenesis	activates	pathway	0.60
Dna Methylation	associated_with	pathway	0.60
Complement	associated_with	pathway	0.60

Incoming (6)

Source	Relation	Type	Str
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
STX17	associated_with	gene	0.60
ATP5MC1	associated_with	gene	0.60
TXNRD1	associated_with	gene	0.60
MFN2	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UNG in their description or question text

No additional research found