gene

SRSF3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SRSF3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

8Outgoing

19Incoming

0Experiments

0Debates

Summary

SRSF3 (Serine/Arginine-Rich Splicing Factor 3) is an essential RNA-binding protein involved in pre-mRNA splicing, alternative splicing regulation, and RNA metabolism. Dysregulated in ALS, AD, PD, and multiple cancers.

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🧬 Gene Info

Gene Symbol	SRSF3
Full Name	Serine/Arginine-Rich Splicing Factor 3
Chromosome	6p21.33
Function	is an essential RNA-binding protein that plays critical roles in pre-mRNA splicing, alternative splicing regulation, mRNA export, and translation.
Molecular Weight	19 kDa
Amino Acids	248 aa
Exons	4
Pathways	Rna Splicing
UniProt ID	P84104
NCBI Gene ID	6734
Ensembl ID	ENSG00000161547
GeneCards	SRSF3
Human Protein Atlas	SRSF3
Associated Diseases	ALS
Interactions	ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, ASTROCYTE, ASTROCYTES
KG Connections	27 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SRSF3 — AlphaFold P84104 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SRSF3 Gene

gene · 2540 words

→

SRSF3 Protein

protein · 643 words

→

Pathway Diagram

graph TD
    SRSF3["SRSF3"]
    P53["p53"]
    IL6["IL-6"]
    NGF["NGF"]
    CYTOKINES["Cytokines"]
    ASTROCYTES["Astrocytes"]
    RNA_SPLICING["RNA Splicing"]
    SENESCENCE["Cellular Senescence"]
    NEURODEGENERATION["Neurodegeneration"]
    ALZHEIMER["Alzheimer's Disease"]
    ALS["Amyotrophic Lateral Sclerosis"]
    AGING["Aging"]
    NEUROTOXICITY["Neurotoxicity"]

    P53 -->|"activates"| SRSF3
    IL6 -->|"activates"| SRSF3
    NGF -->|"activates"| SRSF3
    CYTOKINES -->|"activates"| SRSF3
    ASTROCYTES -->|"activates"| SRSF3
    NEUROTOXICITY -->|"activates"| SRSF3
    
    SRSF3 -->|"regulates"| RNA_SPLICING
    SRSF3 -->|"promotes"| SENESCENCE
    SRSF3 -->|"contributes to"| NEURODEGENERATION
    SRSF3 -->|"activates"| ALZHEIMER
    SRSF3 -->|"activates"| ALS
    SRSF3 -->|"promotes"| AGING

    style SRSF3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style RNA_SPLICING fill:#4a1a6b
    style P53 fill:#4a1a6b
    style NGF fill:#1b5e20
    style SENESCENCE fill:#ef5350
    style NEURODEGENERATION fill:#ef5350
    style ALZHEIMER fill:#7d4200
    style ALS fill:#7d4200
    style AGING fill:#7d4200
    style NEUROTOXICITY fill:#ef5350
    style CYTOKINES fill:#ef5350
    style IL6 fill:#ef5350
    style ASTROCYTES fill:#4a1a6b

Outgoing (8)

Target	Relation	Type	Str
Aging	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Senescence	activates	disease	0.65
Alzheimer	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Rna Splicing	activates	pathway	0.60
ALS	associated_with	disease	0.60

Incoming (19)

Source	Relation	Type	Str
NGF	activates	gene	0.60
HNRNPA1	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
SRSF1	associated_with	gene	0.60
SRSF2	associated_with	gene	0.60
NEUROTOXICITY	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
CYTOKINES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
P53	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
IL-6	activates	gene	0.60
ALS	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
SRSF1	co_expressed_with	protein	0.50
SRSF2	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SRSF3 in their description or question text

No additional research found