gene

SPTLC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPTLC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

24Outgoing

21Incoming

0Experiments

0Debates

Summary

SPTLC2 (Serine Palmitoyltransferase Long Chain Base Subunit 2) encodes the small subunit of serine palmitoyltransferase, a critical enzyme in sphingolipid biosynthesis. Mutations cause hereditary sensory neuropathy; dysregulation implicated in Alzheimer's and Parkinson's diseases.

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🧬 Gene Info

Gene Symbol	SPTLC2
Full Name	Serine Palmitoyltransferase Long Chain Base Subunit 2
Chromosome	14q31.3
Function	### Serine Palmitoyltransferase Activity
Primary Expression	various brain regions:
Molecular Weight	62 kDa
Amino Acids	422 aa
Exons	12
UniProt ID	O15270
NCBI Gene ID	9517
Ensembl ID	ENSG00000166800
OMIM	610313
GeneCards	SPTLC2
Human Protein Atlas	SPTLC2
Associated Diseases	Neuropathy
Interactions	ADRA2A, ALDH1A2, ALS, GENES, IDH1, IRS1
KG Connections	45 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SPTLC2 — AlphaFold O15270 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SPTLC2 Gene

gene · 1612 words

→

SPTLC2 Protein

protein · 635 words

→

Pathway Diagram

graph TD
    SPTLC2["SPTLC2"]
    Als["Als"]
    SPTLC2 -->|"expressed in"| Als
    Cardiovascular["Cardiovascular"]
    SPTLC2 -->|"expressed in"| Cardiovascular
    ALS["ALS"]
    SPTLC2 -->|"expressed in"| ALS
    Neuropathy["Neuropathy"]
    SPTLC2 -->|"associated with"| Neuropathy
    SPTLC1["SPTLC1"]
    SPTLC2 -->|"expressed in"| SPTLC1
    Lipid_Metabolism["Lipid Metabolism"]
    SPTLC2 -->|"expressed in"| Lipid_Metabolism
    SPTLC1["SPTLC1"]
    SPTLC2 -->|"regulates"| SPTLC1
    ABCA1["ABCA1"]
    SPTLC2 -->|"regulates"| ABCA1
    Cholesterol["Cholesterol"]
    SPTLC2 -->|"interacts with"| Cholesterol
    Macrophage["Macrophage"]
    SPTLC2 -->|"interacts with"| Macrophage
    Sphingolipid["Sphingolipid"]
    SPTLC2 -->|"expressed in"| Sphingolipid
    SPTLC1["SPTLC1"]
    SPTLC1 -->|"expressed in"| SPTLC2
    GENES["GENES"]
    GENES -->|"expressed in"| SPTLC2
    AND["AND"]
    AND -->|"expressed in"| SPTLC2
    AND["AND"]
    AND -->|"associated with"| SPTLC2
    ABCA1["ABCA1"]
    ABCA1 -->|"regulates"| SPTLC2
    AND["AND"]
    AND -->|"regulates"| SPTLC2
    Ca1["Ca1"]
    SPTLC2 -->|"expressed in"| Ca1
    Macrophage["Macrophage"]
    SPTLC2 -->|"expressed in"| Macrophage
    CLUSTERIN["CLUSTERIN"]
    CLUSTERIN -->|"co discussed"| SPTLC2
    GENES["GENES"]
    GENES -->|"activates"| SPTLC2
    SPTLC1["SPTLC1"]
    SPTLC1 -->|"activates"| SPTLC2
    neurodegeneration["neurodegeneration"]
    SPTLC2 -->|"implicated in"| neurodegeneration

Outgoing (24)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Neuropathy	associated_with	disease	0.65
Sphingolipid	expressed_in	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
ALS	interacts_with	disease	0.60
neurons	expressed_in	cell_type	0.60
SYNE2	activates	gene	0.60
Ras	expressed_in	protein	0.60
App	expressed_in	protein	0.60
Raf	interacts_with	protein	0.60
Ras	regulates	protein	0.60
Rb	expressed_in	protein	0.60
Lipid Metabolism	expressed_in	pathway	0.60
Cholesterol	interacts_with	pathway	0.60
Macrophage	interacts_with	cell_type	0.60
SPTLC1	expressed_in	gene	0.60
SPTLC1	regulates	gene	0.60
ABCA1	regulates	gene	0.60
Ca1	expressed_in	brain_region	0.55
Macrophage	expressed_in	cell_type	0.55
SERINE PALMITOYLTRANSFERASE	regulates	protein	0.50
SPTLC1	interacts_with	gene	0.50

Incoming (21)

Source	Relation	Type	Str
SPTLC1	regulates	gene	0.60
SPTLC1	interacts_with	gene	0.60
ALS	associated_with	gene	0.60
ALS	interacts_with	gene	0.60
IRS1	activates	gene	0.60
SPTLC1	expressed_in	gene	0.60
ABCA1	regulates	gene	0.60
P2RX1	activates	gene	0.60
AND	expressed_in	gene	0.60
AND	associated_with	gene	0.60
AND	regulates	gene	0.60
LPL	activates	gene	0.60
GENES	expressed_in	gene	0.60
ADRA2A	activates	gene	0.60
ALDH1A2	activates	gene	0.60
IDH1	activates	gene	0.60
ITPKA	activates	gene	0.60
CLUSTERIN	co_discussed	protein	0.50
SPTLC1	activates	gene	0.50
ABCA1	co_expressed_with	gene	0.50
GENES	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SPTLC2 in their description or question text

No additional research found