SMA

Which proteins are differentially expressed in AD CSF and brain tissue, and do t

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Is a 12-protein CSF panel superior to existing plasma p-tau217 for clinical AD p

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Plasma Claudin-5 Proteolytic Fragments Distinguish Paracellular BBB Breakdown fr

Score: 0.705 · unknown disease · 2026-04-26

Claudin-5 is the most abundant tight junction protein in brain endothelial cells and is specifically degraded during ear

Plasma D-Dimer Elevation Reflects Fibrinogen Leakage and Secondary Fibrinolysis

Score: 0.685 · unknown disease · 2026-04-26

Plasma fibrinogen leaks across the compromised BBB and undergoes coagulation cascade activation and cross-linking by fac

Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mismatch Repair Modula

Score: 0.681 · neurodegeneration · 2026-04-04

## Mechanistic Overview Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mismatch Repair Modulation starts from

Small Molecule Modulation of Phase Separation

Score: 0.640 · neurodegeneration · 2026-04-21

**Molecular Mechanism and Rationale** The therapeutic strategy centers on modulating liquid-liquid phase separation (LL

Blocking Tau Packaging into Small Extracellular Vesicles via ESCRT-III Pathway

Score: 0.610 · neuroscience · 2026-04-22

## Mechanistic Overview Blocking Tau Packaging into Small Extracellular Vesicles via ESCRT-III Pathway starts from the c

Neurovascular Permeability Score (NVPS): Composite Plasma + Imaging Biomarker Pa

Score: 0.600 · unknown disease · 2026-04-26

A LASSO-optimized composite score integrating plasma GFAP, S100B, NFL, soluble PDGFR-β, and claudin-5 fragments to achie

APOE4 Structural Correction by Small Molecule Correctors

Score: 0.580 · neurodegeneration · 2026-04-22

## Mechanistic Overview APOE4 Structural Correction by Small Molecule Correctors starts from the claim that modulating A

Structure-interacting small molecules that stabilize the APOE4 molten globule do

Score: 0.580 · neuroscience · 2026-04-22

## Mechanistic Overview Structure-interacting small molecules that stabilize the APOE4 molten globule domain (Domain III

Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuro

Score: 0.560 · neurodegeneration · 2026-04-14

## Mechanistic Overview Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuron Protection sta

Small-Molecule FUS Nuclear Import Correctors Rescue Motor Neuron Toxicity

Score: 0.550 · neurodegeneration · 2026-04-26

ALS-linked FUS mutations (P525L, R521C) impair nuclear import via karyopherin-β2 (Transportin-1), causing cytoplasmic ac

Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables L

Score: 0.485 · unknown disease · 2026-04-26

Neurofilament light chain (NfL) is released from damaged neurofilaments into the extracellular space, flowing into CSF a

Plasma TREM2 Ectodomain Glycosylation Pattern as Therapeutic Response Predictor

Score: 0.427 · biomarkers · 2026-04-26

Site-specific glycosylation patterns on circulating TREM2 ectodomain fragments reflect the metabolic state and activatio

MT1 Receptor Activation at Low Doses Synchronizes Suprachiasmatic Nucleus and Re

Score: 0.405 · unknown disease · 2026-04-26

At doses of 25-50 mg, trazodone's metabolite mCPP exhibits partial agonist activity at melatonin MT1 receptors, phase-ad

Small-Molecule Modulation of G3BP1 Condensate Dynamics via PRMT1 Methylation as

Score: 0.400 · neurodegeneration · 2026-04-22

## Mechanistic Overview Small-Molecule Modulation of G3BP1 Condensate Dynamics via PRMT1 Methylation as a Therapeutic St

Dynamic Plasma Exosome-Derived Multi-Analyte Panel Combining YKL-40, sTREM2, and

Score: 0.389 · biomarkers · 2026-04-26

This hypothesis proposes that plasma-derived exosomes carrying YKL-40, sTREM2, and neurogranin provide a superior biomar