| Gene Symbol | PSMA4 |
| Full Name | Proteasome Subunit Alpha 4 |
| Chromosome | 15q21.3 |
| Function | This ring serves as the gatekeeper for the proteolytic chamber, controlling access of substrates to the catalytic beta subunits. |
| Primary Expression | all tissues, with high expression in metabolically active cells: |
| Molecular Weight | 26 kDa |
| UniProt ID | P25789 |
| NCBI Gene ID | 5685 |
| Ensembl ID | ENSG00000123131 |
| OMIM | 176844 |
| GeneCards | PSMA4 |
| Human Protein Atlas | PSMA4 |
| Brain | Highest expression in cortex, hippocampus, and cerebellum |
| Neuronal subtypes | Expressed in both excitatory glutamatergic neurons and inhibitory GABAergic neurons |
| Glial cells | Present in astrocytes and microglia, where it supports protein homeostasis during neuroinflammation |
| Associated Diseases | neurodegeneration |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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