SIRT
Entity Detail — Knowledge Graph Node
Understanding Entity Pages
This page aggregates everything SciDEX knows about SIRT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Regenerate portrait ↻Wiki Pages (20)
Knowledge base pages for this entity
Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor
idea · 3877 wordsSIRT1 Signaling Pathway in Alzheimer's Disease
pathway · 2490 wordsSPAM1-SIRT6 Positive Allosteric Modulator in Neurodegeneration
mechanism · 1742 wordsSPAM1: SIRT6 Positive Allosteric Modulator
therapeutic · 1688 wordsSIRT1 Activators for Parkinson's Disease
mechanism · 1622 wordsOutgoing (9)
| Target | Relation | Type | Str |
|---|---|---|---|
| NAD+ depletion | causes | mechanism | 0.95 |
| Neurodegeneration | modulates | process | 0.90 |
| Deacetylation | catalyzes | process | 0.90 |
| Longevity | regulates | phenotype | 0.85 |
| IDH-mutant tumors | modulates | unknown | 0.85 |
| Genome Stability | regulates | process | 0.85 |
| NAD+ | degrades | chemical | 0.80 |
| Obesity | associated_with | disease | 0.80 |
| Diabetes | associated_with | disease | 0.80 |
Incoming (1)
| Source | Relation | Type | Str |
|---|---|---|---|
| Calorie Restriction | activates | process | 0.85 |
Targeting Hypotheses (21)
Hypotheses where this entity is a therapeutic target
Mentioning Analyses (0)
Scientific analyses that reference this entity
No analyses mention this entity
Experiments (6)
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Irisin effects on osteogenic differentiation in mesenchymal stem cells | exploratory | bone fracture | 0.900 | 0.00 | mouse bone mesenchymal stem ce | proposed | N/A |
| Epigenetic clocks association with brain aging patterns in older women | exploratory | cognitive impairment and demen | 0.900 | 0.00 | human patients | proposed | N/A |
| iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD | exploratory | Parkinson's disease | 0.900 | 0.00 | iPSC-derived dopaminergic neur | proposed | N/A |
| PGC-1α knockout analysis of PV+ interneuron maturation | validation | neurodevelopmental disorders | 0.850 | 0.00 | knockout mice | proposed | N/A |
| PV+ interneuron subtype diversification analysis | exploratory | neurodevelopmental disorders | 0.750 | 0.00 | mouse cortical PV+ interneuron | proposed | N/A |
| Sirtuin Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Related Papers (20)
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730] | Zhang Y, Jiang H, Zhang F, Liao J | Neural regeneration research | 2026 | 0 |
| The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859] | Qi L, Yi J, Shen Y, Jiang H, Yao X et al | Biochem Pharmacol | 2026 | 0 |
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969] | Wang Y, Yuan Q | Clin Exp Pharmacol Physiol | 2026 | 0 |
| Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899] | Yuanyuan Fang; Mengqiu Deng; Kesheng Hua | Cell communication and signali | 2026 | 0 |
| Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653] | Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y | Journal of diabetes | 2026 | 0 |
| Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101] | Cheng YL, Su MS, Liao CC, Chang TW, Hsie | Journal of microbiology, immun | 2026 | 0 |
| Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436] | Shan C, Szili-Torok T, Yue G, Zhang L, M | Phytomedicine : international | 2026 | 0 |
| Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550] | ["Gao L", "Shen J", "Gao J", "Li T", "Ya | Antioxidants (Basel, Switzerla | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627] | El-Mahrouk SR, El-Kadi AOS | Archives of toxicology | 2025 | 0 |
| Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796] | Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu | Journal of neuroinflammation | 2025 | 0 |
| Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261] | Yang R, Meng X, Zhao W, Xu SQ, Wang SY, | Bioorganic chemistry | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458] | Pradeepkiran JA, Kshirsagar S, Alvir RV, | Biochimica et biophysica acta. | 2025 | 0 |
| The effects of Honokiol on the liver of Alzheimer's disease mice by upregulating [PMID:40776632] | Wang H, Liu J, Tian YR, Zhu F, Li H | Journal of Alzheimer's disease | 2025 | 0 |
| SIRT1 and SIRT6: The role in aging-related diseases. [PMID:37499928] | You Y, Liang W | Biochim Biophys Acta Mol Basis | 2023 | 0 |
| SIRT1 and SIRT6: The role in aging-related diseases. [PMID:37499928] | You Y, Liang W | Biochimica et biophysica acta. | 2023 | 0 |
Debates (0)
Multi-agent debates referencing this entity
No debates reference this entity
Related Research
Hypotheses and analyses mentioning SIRT in their description or question text
TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging
Score: 0.744 · neurodegeneration · 2026-04-12
**Molecular Mechanism and Rationale** The TREM2-SIRT1 metabolic senescence circuit represents a critical regulatory net
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Mitophagy D
Score: 0.738 · Alzheimer's Disease · 2026-04-02
## Mechanistic Overview SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Mitophagy Dysfunction start
Metabolic Inflexibility Precedes Transcriptional Reprogramming (NAD+/SIRT3 Axis)
Score: 0.735 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The NAD+/SIRT3 axis represents a critical regulatory hub controlling mitochondria
NAD+ Decline and SIRT1 Deficiency Drive Epigenetic Reprogramming Toward Senescen
Score: 0.700 · neurodegeneration · 2026-04-22
## **Molecular Mechanism and Rationale** The molecular foundation of this hypothesis centers on the intricate relations
LRRK2 Volume Sensor Hijacking Drives Metabolic Dysregulation via SIRT1/PGC1α Sup
Score: 0.666 · neurodegeneration · 2026-04-16
## Mechanistic Overview LRRK2 Volume Sensor Hijacking Drives Metabolic Dysregulation via SIRT1/PGC1α Suppression starts
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.612 · neurodegeneration · 2026-04-02
## Mechanistic Overview SIRT6-NAD+ Axis Enhancement Therapy starts from the claim that modulating SIRT6 within the disea
NRF2-Mediated Metabolic Reprogramming: HBOT as Direct NAMPT/SIRT1 Activator for
Score: 0.602 · neurodegeneration · 2026-04-17
## Mechanistic Overview NRF2-Mediated Metabolic Reprogramming: HBOT as Direct NAMPT/SIRT1 Activator for Reverse Senescen
NAMPT-SIRT1 Axis as Master Regulator of SASP-Dependent Complement Amplification
Score: 0.592 · neurodegeneration · 2026-04-16
## Mechanistic Overview NAMPT-SIRT1 Axis as Master Regulator of SASP-Dependent Complement Amplification starts from the
SIRT3 loss creates a mitochondrial acetylation-stress loop that weakens antioxid
Score: 0.560 · neurodegeneration · 2026-04-25
Declining SIRT3 activity leaves SOD2, IDH2, and permeability-transition regulators hyperacetylated, reducing mitochondri
SIRT1 Activation Suppresses C9orf72-Mediated Neurodegeneration
Score: 0.560 · neurodegeneration · 2026-04-28
SIRT1 activation promotes mitophagy via PINK1/Parkin, reduces oxidative stress, and decreases DPR levels in cellular mod
SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression Re-enables SPM Precur
Score: 0.500 · neuropharmacology · 2026-04-13
## Mechanistic Overview SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression Re-enables SPM Precursor Transport in
SIRT3 gates microglial surveillance versus primed metabolism through mitochondri
Score: 0.482 · neuroinflammation · 2026-04-21
## Mechanistic Overview SIRT3 gates microglial surveillance versus primed metabolism through mitochondrial deacetylation
SIRT1 Activator Therapy for Mitochondrial Epigenetic Dysregulation
Score: 0.480 · neurodegeneration · 2026-04-25
SIRT1 Activator Therapy for Mitochondrial Epigenetic Dysregulation
NAD+-SIRT1-H3K9me3 restoration enables true senescence reversal, while incomplet
Score: 0.380 · Alzheimer's disease · 2026-04-26
Partial metabolic interventions (e.g., mTOR inhibition alone) suppress SASP secretion but leave growth arrest intact bec