| Gene Symbol | SPAM1 |
| Full Name | SIRT6 Positive Allosteric Modulator in Neurodegeneration |
| Chromosome | 19p13.3. |
| GeneCards | SPAM1 |
| Human Protein Atlas | SPAM1 |
| Blood-brain barrier penetration | Demonstrated rapid brain targeting with detectable levels within 10 minutes of administration, peak levels at 1 hour, and sustained presence for over 12 hours |
| Activity at 1 μM | Optimal anti-senescence effects observed in cellular models at 1 μM concentration |
| Allosteric mechanism | Does not directly bind the SIRT6 catalytic domain; instead activates through a receptor-mediated pathway |
| α-synuclein aggregation | SIRT6 may regulate chaperone systems that influence protein aggregation. |
| Neuroinflammation | NF-κB suppression by SIRT6 reduces microglial activation that contributes to dopaminergic neuron loss. |
| Mitochondrial dysfunction | SIRT6 regulates PGC-1α activity, influencing mitochondrial biogenesis and function in neurons. |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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