concept

SHORT-CHAIN FATTY ACIDS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SHORT-CHAIN FATTY ACIDS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

5Analyses

34Outgoing

11Incoming

0Experiments

7Debates

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💡 Concept Info

Name	SHORT-CHAIN FATTY ACIDS

Pathway Diagram

graph TD
    SHORT_CHAIN_FATTY_ACIDS["SHORT-CHAIN FATTY ACIDS"]
    SHORT_CHAIN_FATTY_ACIDS -.protects against.-> Blood_Brain_Barrier["Blood-Brain Barrier"]
    SHORT_CHAIN_FATTY_ACIDS -->|"mediates"| Microbiota_Brain_Axis["Microbiota-Brain Axis"]
    SHORT_CHAIN_FATTY_ACIDS -->|"modulates"| Neuroinflammation["Neuroinflammation"]
    SHORT_CHAIN_FATTY_ACIDS -->|"regulates"| JUNCTIONAL_COMPLEX_PROTEINS["JUNCTIONAL COMPLEX PROTEINS"]
    SHORT_CHAIN_FATTY_ACIDS -->|"binds"| G_PROTEIN_COUPLED_RECEPTORS["G-PROTEIN-COUPLED RECEPTORS"]
    SHORT_CHAIN_FATTY_ACIDS -->|"modulates"| Alpha_Synuclein_Aggregation["Alpha-Synuclein Aggregation"]
    SHORT_CHAIN_FATTY_ACIDS -->|"risk_factor_for"| Hypertension["Hypertension"]
    SHORT_CHAIN_FATTY_ACIDS -->|"modulates"| Microbiota_Gut_Brain_Axis["Microbiota-Gut-Brain Axis"]
    Anaerobic_Bacterial_Fermentati["Anaerobic Bacterial Fermentation"] -->|"product_of"| SHORT_CHAIN_FATTY_ACIDS
    Gut_Microbiome["Gut Microbiome"] -->|"product_of"| SHORT_CHAIN_FATTY_ACIDS
    Dietary_Fiber["Dietary Fiber"] -->|"involved_in"| SHORT_CHAIN_FATTY_ACIDS
    Maternal_Microbiota["Maternal Microbiota"] -->|"upregulates"| SHORT_CHAIN_FATTY_ACIDS
    Parkinson_s_Disease["Parkinson's Disease"] -->|"correlates_with"| SHORT_CHAIN_FATTY_ACIDS
    Probiotics["Probiotics"] -->|"upregulates"| SHORT_CHAIN_FATTY_ACIDS

Outgoing (34)

Target	Relation	Type	Str
Blood-Brain Barrier	protects_against	process	0.95
SNCA	modulates	protein	0.95
Microbiota-Brain Axis	mediates	pathway	0.90
Alpha-Synuclein Aggregation	modulates	process	0.90
JUNCTIONAL COMPLEX PROTEINS	regulates	protein	0.90
G-PROTEIN-COUPLED RECEPTORS	binds	receptor	0.90
Neuroinflammation	modulates	process	0.90
Parkinson'S Disease	associated_with	disease	0.90
Hypertension	risk_factor_for	disease	0.85
Cardiovascular Disease	risk_factor_for	disease	0.85
Gut-Brain Axis	involved_in	pathway	0.85
Neuroinflammation	suppresses	process	0.85
Oxidative Stress	suppresses	process	0.85
MTOR	modulates	gene	0.85
Parkinson's Disease	protects_against	disease	0.85
Microbiota-Gut-Brain Axis	modulates	pathway	0.85
Microbiota-Gut-Brain Axis	mediates	pathway	0.85
HISTONE DEACETYLASES	inhibits	enzyme	0.85
neuroinflammation	suppresses	process	0.80
Blood-Brain Barrier Integrity	protects_against	phenotype	0.80
mTOR Pathway	activates	pathway	0.80
NEUROINFLAMMATION	inhibits	process	0.75
Microglial Activation	modulates	process	0.75
Parkinson's Disease	treats	disease	0.75
Gastrointestinal Tract	mediates	cell_type	0.75
TREM2-mediated microglial activation	regulates	mechanism	0.70
TREM2-mediated microglial activation	activates	phenotype	0.70
microglial_activation	inhibits	phenotype	0.70
alpha_synuclein_aggregation	inhibits	phenotype	0.70
Autophagic Clearance	enhances	phenotype	0.70
neuroinflammation	modulates	mechanism	0.70
neuroinflammation	inhibits	mechanism	0.70
Parkinson's disease	modulates	disease	0.70
microglial anti-inflammatory phenotype	causes	cell_type	0.70

Incoming (11)

Source	Relation	Type	Str
Gut Microbiome	associated_with	process	0.95
Anaerobic Bacterial Fermentation	product_of	process	0.95
Dietary Fiber	involved_in	compound	0.90
Prevotellaceae	associated_with	gene	0.90
Bifidobacterium	associated_with	cell_type	0.90
Maternal Microbiota	upregulates	process	0.90
Parkinson's Disease	correlates_with	disease	0.80
Probiotics	associated_with	drug	0.80
Probiotics	upregulates	drug	0.75
38934394	mediate	paper	0.60
38934394	mediates	paper	0.60