concept

ALPHA-SYNUCLEIN AGGREGATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALPHA-SYNUCLEIN AGGREGATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

4Hypotheses

1Analyses

13Outgoing

20Incoming

0Experiments

1Debates

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💡 Concept Info

Name	ALPHA-SYNUCLEIN AGGREGATION

Pathway Diagram

graph TD
    ALPHA_SYNUCLEIN_AGGREGATION["ALPHA-SYNUCLEIN AGGREGATION"]
    ALPHA_SYNUCLEIN_AGGREGATION -->|"causes"| Parkinson_s_Disease["Parkinson's Disease"]
    ALPHA_SYNUCLEIN_AGGREGATION -->|"causes"| Neurodegeneration["Neurodegeneration"]
    ALPHA_SYNUCLEIN_AGGREGATION -->|"causes"| CNS_Inflammation["CNS Inflammation"]
    ALPHA_SYNUCLEIN_AGGREGATION -->|"interacts"| Mitochondrial_Dysfunction["Mitochondrial Dysfunction"]
    Short_Chain_Fatty_Acids["Short-Chain Fatty Acids"] -->|"modulates"| ALPHA_SYNUCLEIN_AGGREGATION
    BMAL1["BMAL1"] -->|"promotes"| ALPHA_SYNUCLEIN_AGGREGATION
    Piperine["Piperine"] -->|"inhibits"| ALPHA_SYNUCLEIN_AGGREGATION
    ceftriaxone["ceftriaxone"] -->|"inhibits"| ALPHA_SYNUCLEIN_AGGREGATION
    Polyamines["Polyamines"] -->|"modulates"| ALPHA_SYNUCLEIN_AGGREGATION
    Ceftriaxone["Ceftriaxone"] -->|"inhibits"| ALPHA_SYNUCLEIN_AGGREGATION
    SNCA["SNCA"] -->|"involved_in"| ALPHA_SYNUCLEIN_AGGREGATION

Outgoing (13)

Target	Relation	Type	Str
Parkinson's Disease	causes	disease	0.95
Parkinson's Disease	associated_with	disease	0.95
Mitochondrial Depolarization	causes	phenotype	0.93
Dopaminergic Neurons	causes	cell_type	0.92
Parkinson's Disease	causes	disease	0.90
ATP Production	downregulates	phenotype	0.90
microtubule destabilization	drives	process	0.90
Autophagy-Lysosomal Pathway	involved_in	pathway	0.90
Parkinson's Disease	contributes_to	disease	0.90
Mitochondrial Fragmentation	causes	phenotype	0.89
CNS Inflammation	causes	process	0.85
dopaminergic neuron loss	contributes_to	phenotype	0.85
Neurodegeneration	causes	process	0.85

Incoming (20)

Source	Relation	Type	Str
SNCA	involved_in	gene	0.95
D-520	suppresses	drug	0.90
SNCA	causes	gene	0.90
Short-Chain Fatty Acids	modulates	compound	0.90
Piperine	inhibits	compound	0.90
BMAL1	promotes	gene	0.90
BMAL1	inhibits	gene	0.85
ceftriaxone	inhibits	drug	0.85
SNCA	regulates	gene	0.85
gut microbiota	promotes	process	0.80
neuroinflammation	promotes	process	0.80
Polyamines	modulates	compound	0.80
SNCA	involved_in	protein	0.80
Ceftriaxone	inhibits	drug	0.80
SCFAS	inhibits	compound	0.80
curli fibrils	causes	biomarker	0.70
Dorsal Motor Nucleus of the Vagus Nerve	associated_with	cell_type	0.70
Olfactory Bulb	associated_with	cell_type	0.70
Ferroptosis	modulates	process	0.70
Curli fibrils	causes	protein	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
m6A-dependent control of alpha-synuclein transcript fate and	0.626	neurodegeneration	m6A RNA Modification and Alpha-Synuclein
Cell-state stratification is required to resolve m6A RNA Mod	0.612	neurodegeneration	m6A RNA Modification and Alpha-Synuclein
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	m6A RNA Modification and Alpha-Synuclein
Glucosylceramide accumulation nucleates alpha-synuclein aggr	0.525	Parkinson's disease	GBA-Synuclein Loop Therapeutics for PD

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.907

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning ALPHA-SYNUCLEIN AGGREGATION in their description or question text

No additional research found